Results 91 to 100 of about 3,573,227 (298)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A Semantic-Based Information Management System to Support Innovative Product Design [PDF]

, 2003
International competition and the rapidly global economy, unified by improved communication and transportation, offer to the consumers an enormous choice of goods and services.
Conti, Giuseppe, De Amicis, Raffaele, Giunchiglia, Fausto, Noll, Stefan, Ucelli, Giuliana   +4 more
core  

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Fit for purpose? Evaluating multiple-choice question quality in E-learning for emergency primary healthcare

Cogent Public Health
Objective Emergency medicine healthcare professionals need to be continuously updated and trained in emergency medicine. Continuing professional development (CPD) courses are frequently offered but are seldom quality assured by other means than learner ...
Kate-Torunn Aas Vold, Monika Kvernenes, Une Elisabeth Stømer, Erik Zakariassen   +3 more
doaj   +1 more source

STUDY ON THE HERITABILITY OF MILK PRODUCTION IN A LINE OF HOLSTEIN FREISE [PDF]

AgroLife Scientific Journal, 2015
Livestock genetical structure improvement from one generation to another request, among others, the knowledge of their genetical parameters. The guidance of livestock genetical structure involves the knowledge of the share caused by genetical and ...
Tomiţa DRAGOTOIU, Nicoleta IŞFAN, Loredana STROILESCU, Dumitru DRAGOTOIU, Monica MARIN, Izabela OPREA   +5 more
doaj  

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

An open source infrastructure for managing knowledge and finding potential collaborators in a domain-specific subset of PubMed, with an example from human genome epidemiology

BMC Bioinformatics, 2007
Background Identifying relevant research in an ever-growing body of published literature is becoming increasingly difficult. Establishing domain-specific knowledge bases may be a more effective and efficient way to manage and query information within ...
Khoury Muin J, Qu Junfeng, Wulf Anja, Yesupriya Ajay, Yu Wei, Gwinn Marta   +5 more
doaj   +1 more source

Building a Learning Organization [PDF]

, 2009
{Excerpt} A learning organization values the role that learning can play in developing organizational effectiveness. It demonstrates this by having an inspiring vision for learning and a learning strategy that will support the organization in achieving ...
Serrat, Olivier
core   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source