Results 31 to 40 of about 635,246 (293)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

FOOD CHOICES AND KNOWLEDGE ABOUT DISEASES ASSOCIATED AMONG PRIVATE UNIVERSITY STUDENTS IN SHAH ALAM, MALAYSIA

open access: yesGlobal Journal of Public Health Medicine, 2019
Introduction: Diet related diseases are diseases in human body for a long period of time that is not dangerous and it can be preventable. This diet related diseases occur due to poor eating habits.
Yogesraj Selvamoney   +1 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Large language models for closed-library multi-document query, test generation, and evaluation

open access: yesFrontiers in Artificial Intelligence
IntroductionLearning complex, detailed, and evolving knowledge is a challenge in multiple technical professions. Relevant source knowledge is contained within many large documents and information sources with frequent updates to these documents ...
Claire Randolph   +2 more
doaj   +1 more source

Pembuatan Aplikasi Mobile Learning sebagai Sarana Pembelajaran di Lingkungan Universitas Diponegoro

open access: yesJurnal Teknologi dan Sistem Komputer, 2013
Mobile learning is the intersection of Mobile Computing and E-Learning that provides the resources that can be accessed from anywhere, a powerful search system capabilities, rich interaction, full support for effective learning and assessment based on ...
Afandi Nur Aziz Thohari   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

NETME: on-the-fly knowledge network construction from biomedical literature

open access: yesApplied Network Science, 2022
Background The rapidly increasing biological literature is a key resource to automatically extract and gain knowledge concerning biological elements and their relations.
Alessandro Muscolino   +9 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Knowledge Patterns and Knowledge Refactorings for Increasing the Quality of Knowledge

open access: yes, 2022
S.281-328Knowledge management is a relatively young discipline. It has accumulated a valuable body-of-knowledge on how to structure and represent knowledge, or how to design socio-technical knowledge management systems.
Rech, J.   +4 more
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