Results 41 to 50 of about 635,246 (293)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Knowledge Graph Building Blocks: An easy-to-use Framework for developing FAIREr Knowledge Graphs

CoRR, 2023
Knowledge graphs and ontologies provide promising technical solutions for implementing the FAIR Principles for Findable, Accessible, Interoperable, and Reusable data and metadata. However, they also come with their own challenges. Nine such challenges are discussed and associated with the criterion of cognitive interoperability and specific FAIREr ...
Lars Vogt, Marcel Konrad, Manuel Prinz
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

CONSIDERATIONS REGARDING KNOWLEDGE MANAGEMENT [PDF]

Journal of Defense Resources Management, 2010
Knowledge management is the process by which the organizations generate wealth from their intellectual assets putting both tacit and explicit knowledge into action.
Brînduşa Maria POPA
doaj  

CLOCQ: A Toolkit for Fast and Easy Access to Knowledge Bases

, 2023
Curated knowledge bases (KBs) store vast amounts of factual world knowledge, and are therefore ubiquitous in many information retrieval (IR) and natural language processing (NLP) applications like question answering, named entity disambiguation, or knowledge exploration.
Christmann, P., Saha Roy, R., Weikum, G.
openaire   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Sample size calculations made easy using G*Power [PDF]

, 2018
G*power is a free software that helps researchers to calculate the sample size needed when conducting a research. The importance of sample size calculation is imperative for the knowledge of researchers.
Wan Ahmad, Wan Muhamad Amir, Khamis, Mohd Fadhli, Mohd Ibrahim, Mohamad Shafiq, Husein, Adam   +3 more
core  

Cross-modal contrastive learning-based object detection under incomplete modalities

Geo-spatial Information Science
Object detection demonstrates stronger performance when using multimodal remote-sensing images than when using single-modal data. However, in practical applications, some modalities may be unavailable in a specific area, which limits the application of ...
Hongjun Ma, Huan Ni, Yongshi Jie, Haiyan Guan, Qingli Luo   +4 more
doaj   +1 more source

Triads in dermatology

Indian Journal of Dermatology, 2013
It is imperative for any dermatology resident to have a good knowledge of the various triads in dermatology. For an easy grasp over this topic, we have grouped the various triads on the basis of their etiologies.
Prachi G Agrawal, Uday S Khopkar, Sunanda A Mahajan, Sunil N Mishra   +3 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source