Results 61 to 70 of about 578,531 (251)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Heterogeneous Ontology Repository for Intelligent E-Learning
Applied SciencesA large number of ontologies have been developed over the past two decades for the education domain. Some of these ontologies are available in public repositories published within the Linked Open Data cloud.
Tatyana Ivanova
doaj +1 more source
Auditory processing in children: Role of working memory and lexical ability in auditory closure.
PLoS ONE, 2020 We examined the relationship between cognitive-linguistic mechanisms and auditory closure ability in children. Sixty-seven school-age children recognized isolated words and keywords in sentences that were interrupted at a rate of 2.5 Hz and 5 Hz.
Naveen K Nagaraj, Beula M Magimairaj
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Jixie chuandong, 2008 The characteristics,steps and knowledge formation of mechanism design are analyzed,and the multidimensional cubic data model and its knowledge database based on the principle of data mining are proposed.
王冬梅
doaj
Knowledge management and marketing [PDF]
Marketing (Beograd. 1991), 2003 Looking at concepts of which management theory is created at the beginning of XXI century is not an easy research task. In this paper we try to look at some core assumptions and characteristics of Knowledge Management concept.
Mašić Branislav M.
doaj
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Cogent Public HealthObjective Emergency medicine healthcare professionals need to be continuously updated and trained in emergency medicine. Continuing professional development (CPD) courses are frequently offered but are seldom quality assured by other means than learner ...
Kate-Torunn Aas Vold +3 more
doaj +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source