Results 51 to 60 of about 239,945 (258)

An Intuitive Automated Modelling Interface for Systems Biology [PDF]

Electronic Proceedings in Theoretical Computer Science, 2009
We introduce a natural language interface for building stochastic pi calculus models of biological systems. In this language, complex constructs describing biochemical events are built from basic primitives of association, dissociation and transformation.
Ozan Kahramanoğulları, Luca Cardelli, Emmanuelle Caron   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Pre-mRNA trans-splicing: from kinetoplastids to mammals, an easy language for life diversity

Memorias do Instituto Oswaldo Cruz, 2005
Since the discovery that genes are split into intron and exons, the studies of the mechanisms involved in splicing pointed to presence of consensus signals in an attempt to generalize the process for all living cells. However, as discussed in the present
Mario Gustavo Mayer, Lucile Maria Floeter-Winter   +1 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

REVIEW: Carving a niche for minority language media studies not so easy

Pacific Journalism Review, 2014
Book review of: Social Media and Minority Languages: Convergence and the Creative Industries, edited by Elin Haf Gruffydd Jones and Enrique Uribe-Jongbloed. Bristol, UK: Multilinguial Matters, 2013, 267pp.
Philippa Smith
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Translation and Easy-to-Read Language Skills in the Context of Professional Competence in Tourism [PDF]

Acta Universitatis Sapientiae: Philologica
The article is a theoretical study of the role of translation/ interpreting/mediation as the 5th foreign language learning skill (along with the four traditional ones: speaking, listening, reading, writing) in tourism industry studies, taking into ...
Ieva Sproģe
doaj   +1 more source

Take language assessment easy: the mediator impacts of self-assessment, test-taking skills in predicting student evaluation apprehension, foreign language learning self-esteem, and language achievement in online classes

Language Testing in Asia, 2023
Many different elements have a significant impact on the effectiveness of both teaching and assessment. The ever-expanding body of research on assessment has provided an overview of several cognitive, social, and emotional aspects that impact the ...
KDV Prasad, Alaa Aladini, Nozliya Zarilovna Normurodova, Barana Belton   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source