Results 51 to 60 of about 772,644 (300)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Eating pathology in relationship to hopelessness [PDF]

, 2001
Plan BPast research evaluating the continuity and discontinuity hypotheses has produced inconclusive results. The continuity hypothesis states that dieting plays a role in the development of bulimia and disordered eating falls on a continuum.
Laffe, Stacia A.
core  

Implementation of enhanced cognitive behaviour therapy (CBT-E) for adults with anorexia nervosa in an outpatient eating-disorder unit at a public hospital

Journal of Eating Disorders, 2018
Background Anorexia nervosa (AN) in adults is difficult to treat, and no current treatment is supported by robust evidence. A few studies, most of which were performed by highly specialized research units, have indicated that enhanced cognitive behaviour
Stein Frostad, Yngvild S. Danielsen, Guro Å. Rekkedal, Charlotte Jevne, Riccardo Dalle Grave, Øyvind Rø, Ute Kessler   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Psychiatric comorbidity and maternal distress among adolescent eating disorder patients: a comparison with substance use disorder patients

, 2017
High rates of comorbidity are found among eating disorder (ED) patients, which may negatively affect treatment outcome and prognosis. However, there is a shortage of studies in Spain using clinician administered interviews to assess rates of comorbidity ...
Graell, Montserrat, Parks, Melissa, Brugnera, Agostino, Anastasiadou, Dimitra Tatiana, Sepúlveda, Ana R.   +4 more
core   +1 more source

Online cognitive behavioral therapy enhanced for binge eating disorder: study protocol for a randomized controlled trial

BMC Psychiatry, 2020
Background Binge eating disorder is characterized by recurrent episodes of binge eating accompanied by a sense of lack of control. Of the different treatments available, Cognitive Behavioral Therapy-Enhanced and guided self-help treatment are recommended.
Elske van den Berg, Bernou Melisse, Jitske Koenders, Margo de Jonge, Matthijs Blankers, Edwin de Beurs, Jack Dekker   +6 more
doaj   +1 more source

To eat or not to eat

, 2020
Coverage ...
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Physical appearance perfectionism explains variance in eating disorder symptoms above general perfectionism [PDF]

, 2015
Physical appearance perfectionism is a domain-specific form of perfectionism comprising two components: hope for perfection and worry about imperfection (Yang & Stoeber, 2012).
Stoeber, Joachim, Yang, Hongfei
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source