Results 81 to 90 of about 450,257 (265)

Illness severity, treatment motivation and personality as predictors for the treatment outcome in adolescents and young adults with anorexia nervosa

Journal of Eating Disorders
Background Anorexia nervosa (AN) is a severe psychiatric disorder with high chronicity, particularly affecting adolescents. Existing treatments for adolescents do not always lead to full recovery.
Konstantin Kopp, Stefanie Truttmann, Tanja Wittek, Julia Klang, Helene Krauss, Carina Aichinger, Isolde Kostner, Ulrike Schmidt, Andreas Karwautz, Michael Zeiler, Gudrun Wagner   +10 more
doaj   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Ketamine for treatment resistant depression in individuals with eating disorders: a comparison study

Journal of Eating Disorders
Background Individuals with eating disorders (EDs) have an increased risk of treatment resistant depression (TRD) and treatment resistant bipolar disorder (TRBD) and a higher rate of suicidal ideation and death by suicide than individuals without EDs ...
Elizabeth Wassenaar, Dan V. Blalock, Alan Duffy, Megan Riddle, Anne Marie O’Melia, Howard Weeks, Phillip S. Mehler, Renee D. Rienecke   +7 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

DHA, Eat or Not Eat？

International Journal of Psychiatry and Neurology, 2017
目的：目前市场上出售的保健品种类繁多，我们如何选择一种无副作用还能对疾病起到预防作用的保健品呢？DHA (ω-3：7，10，13，16，19-二十二碳六烯酸)作为一种多不饱和脂肪酸，能够通过血脑屏障，是大脑皮层神经元细胞膜的形成的重要原料；改善人类认知功能，减轻阿尔茨海默病和抑郁症的发生；方法：本文把近年来国外对DHA的研究情况作了系统综述。结果与结论：DHA的开发利用己受到世界各国的关注和重视。DHA能够预防和改善精神疾病和神经退行性病变。选择DHA作为一种保健品，不失为一种明智的选择。 Various health products are sold on the market at present. How can we choose a health product which has no
openaire   +1 more source

Clinical heterogeneity of feeding and eating disorders: using personality psychopathology to differentiate “simplex” and “complex” phenotypes

BMC Psychiatry
Background To investigate Feeding and Eating Disorders (FED) heterogeneity based on the co-occurrence of FED symptoms and personality psychopathology, on the hypothesis that empirical profiles would not confirm current FED categories but identify unique ...
Marco Colizzi, Carla Comacchio, Marco Garzitto, Lavinia Bucciarelli, Anna Candolo, Maddalena Cesco, Veronica Croccia, Alessandra Ferreghini, Rosita Martinelli, Alessandra Nicotra, Giulia Sebastianutto, Matteo Balestrieri   +11 more
doaj   +1 more source

Host-specific microbiome-rumination interactions shape methane-yield phenotypes in dairy cattle

mSphere
Enteric methane emissions (EMEs) negatively impact both the environment and livestock efficiency. Given the proposed link between CH4 yield and the rumination time (RT) phenotype, we hypothesize that this connection is mediated by the gut microbiome ...
Alejandro Castaneda, Nagaraju Indugu, Kathryn Lenker, Kapil Narayan, Sarah Rassler, Joseph Bender, Linda Baker, Ojas Purandare, David Chai, Xin Zhao, Dipti Pitta   +10 more
doaj   +1 more source