Results 71 to 80 of about 505,815 (288)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Effectiveness of temperament based therapy with support: a randomized controlled trial study protocol

Frontiers in Psychology
BackgroundTemperament-Based Therapy with Support (TBT-S) is a neurobiologically informed, skills-based intervention for eating disorders in which individuals with anorexia nervosa (AN) and their supports participate together in a multi-family group ...
Kristin Stedal, Ingrid Funderud
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Further evidence of the association between social media use, eating disorder pathology and appearance ideals and pressure: a cross-sectional study in Norwegian adolescents

Journal of Eating Disorders
Background Few studies have investigated how the plethora of contemporary social media (SM) platforms relate to, and influence eating disorder (ED) pathology, appearance ideals and pressure to conform to these ideals in youth. Methods In this study, 1558
Camilla Lindvall Dahlgren, Christine Sundgot-Borgen, Ingela Lundin Kvalem, Anne-Louise Wennersberg, Line Wisting   +4 more
doaj   +1 more source

Transdiagnostic Investigation of Impulsivity in Alcohol Use Disorder and Binge Eating Disorder With Eye-Tracking Methodology—A Pilot Study

Frontiers in Psychiatry, 2019
Objective: Patients with alcohol use disorder (AUD) and patients with binge eating disorder (BED) are characterized by increased impulsivity, i.e. increased reward sensitivity and diminished response inhibition.
Kathrin Schag, Kathrin Schag, Magdalena Rauch-Schmidt, Magdalena Rauch-Schmidt, Friederike Wernz, Stephan Zipfel, Stephan Zipfel, Anil Batra, Katrin E. Giel, Katrin E. Giel   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Digital risks and adolescents: The relationships between digital game addiction, emotional eating, and aggression

, 2021
Nowadays, weight gain and obesity are major health-threatening issues for children. Emotional eating, a negative health condition that can lead to obesity in children, is a defence mechanism for coping with negative emotions.
Nuray Caner, Derya Evgin, Caner, Nuray, Evgin, Derya   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Prevalence and Correlates of Exercise Addiction in the Presence vs. Absence of Indicated Eating Disorders

Frontiers in Sports and Active Living, 2020
Despite the many benefits of regular, sustained exercise, there is evidence that exercise can become addictive, to the point where the exerciser experiences negative physiological and psychological symptoms, including withdrawal symptoms upon cessation ...
Mike Trott, Lin Yang, Lin Yang, Sarah E. Jackson, Joseph Firth, Joseph Firth, Joseph Firth, Claire Gillvray, Claire Gillvray, Claire Gillvray, Brendon Stubbs, Brendon Stubbs, Brendon Stubbs, Lee Smith   +13 more
doaj   +1 more source