Results 141 to 150 of about 141,024 (211)
ABSTRACT Contemporary societies face slow‐burning crises – such as antimicrobial resistance (AMR) – that demand sustained responses from national governments but often elicit uneven action. Policy implementation, public health, and creeping crisis literatures have each proposed factors to explain why governments vary in their responses.
Nicholas Olczak, Mark Rhinard
wiley +1 more source
Abstract Objectives The COVID‐19 pandemic affected mental health worldwide, including obsessive‐compulsive symptoms (OCS) and, specifically, contamination‐related OCS (C‐OCS). This study aimed to map these symptoms' trajectories over four years, thus providing the longest known observational timeline of OCS during and after a pandemic.
Lea Schuurmans +5 more
wiley +1 more source
Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi +2 more
wiley +1 more source
Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery
Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
wiley +1 more source
A Review of Current Computational Tools for Peptide–Protein Docking
In this review, we compare 14 specialized peptide‐protein docking programs, adaptable small‐molecule docking tools, and emerging AI‐driven approaches. By clarifying how each method works, we offer researchers an accessible guide to selecting the most suitable tools for biochemical studies and peptide‐focused drug discovery.
Fábio G. Martins +2 more
wiley +1 more source
Remdesivir as a possible therapeutic option for the COVID-19 [PDF]
Al-Homoud, Ali H. +2 more
core +1 more source

