Results 151 to 160 of about 1,946,344 (262)
Ebola virus: A global public health menace: A narrative review
Ebola virus disease (EVD), a fatal viral hemorrhagic illness, is due to infection with the Ebola virus of the Filoviridae family. The disease has evolved as a global public health menace due to a large immigrant population.
S. Hasan +3 more
semanticscholar +1 more source
Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study. [PDF]
BackgroundClinical sequelae of Ebola virus disease (EVD) have not been described more than 3 years postoutbreak. We examined survivors and close contacts from the 1995 Ebola outbreak in Kikwit, Democratic Republic of Congo (DRC), and determined ...
Bjornson, Zach +15 more
core
ABSTRACT Background Since December 2019, SARS‐CoV‐2 has infected over 700 million people and caused > 7 million deaths. While much of the global north was severely affected, sub‐Saharan Africa was relatively spared. Possible reasons include a younger population, fewer comorbidities, and pre‐existing immunity.
Robert J. Samuels +11 more
wiley +1 more source
Long-lasting severe immune dysfunction in Ebola virus disease survivors
Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18–25]) after discharge
A. Wiedemann +23 more
semanticscholar +1 more source
Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff +2 more
wiley +1 more source
Since the largest 2014–2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators.
Anne-Laure Favier +8 more
doaj +1 more source
Background For most classes of drugs, rapid development of therapeutics to treat emerging infections is challenged by the timelines needed to identify compounds with the desired efficacy, safety, and pharmacokinetic profiles.
Kristen E. Pascal +40 more
semanticscholar +1 more source
The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need.
Shu Yang +34 more
semanticscholar +1 more source
Alix and VPS4A function in HBV biogenesis and degradation in the context of the endosomal and autophagic pathways. Alix and VPS4A orchestrate HBV secretion and degradation via endosomal and autophagic pathways. Under normal conditions, ESCRT ensures efficient virion budding and MVB formation.
Jia Li +5 more
wiley +1 more source
Monoclonal Antibody Therapy for Ebola Virus Disease.
Early reports in 1976 and 1995 documented cases in the Democratic Republic of Congo (DRC) of what we now know to be Ebola virus disease (EVD) caused by Zaire ebolavirus.
M. Levine
semanticscholar +1 more source

