Results 101 to 110 of about 389,890 (305)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Influence of Impaired Upper Extremity Motor Function on Static Balance in People with Chronic Stroke
SensorsBackground: Stroke is a leading cause of disability, especially due to an increased fall risk and postural instability. The objective of this study was to analyze the impact of motor impairment in the hemiparetic UE on static balance in standing, in ...
Ana Mallo-López +4 more
doaj +1 more source
Bond Graph Multi-time Scale Analysis of a Railway Traction System [PDF]
, 2001 The unified formalism of bond graphs is applicable to designing, modeling and analyzing complex and heterogeneous physical systems. Moreover, various order-reduction methods can be applied directly on bond graph models in order to simplify them.
Dauphin-Tanguy, Geneviève +3 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Aerosol and Air Quality ResearchUrbanization and industrialization have contributed to increased air pollution in China, yet few studies have focused on carbon aerosols in Xiangtan. To investigate the temporal variations and origins of carbon aerosols in fine particulate matter (PM2.5)
Lizhi He +4 more
doaj +1 more source
A connectionist approach to embodied conceptual metaphor
Frontiers in Psychology, 2010 A growing body of data has been gathered in support of the view that the mind is embodied and that cognition is grounded in sensory-motor processes. Some researchers have gone so far as to claim that this paradigm poses a serious challenge to central ...
Stephen J Flusberg +3 more
doaj +1 more source
Commission on the Future of Worker-Management Relations; Notice of Closing the Public Record [PDF]
, 1994 Notice_Federal_Register_041894.pdf: 96 downloads, before Oct.
U.S. Government Printing Office
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Design of an Elastic Actuation System for a Gait-Assistive Active Orthosis for Incomplete Spinal Cord Injured Subjects [PDF]
, 2016 A spinal cord injury severely reduces the quality of life of affected people. Following the injury, limitations of the ability to move may occur due to the disruption of the motor and sensory functions of the nervous system depending on the severity of
Stuhlenmiller, Florian
core +1 more source