Results 231 to 240 of about 260,353 (317)

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu   +7 more
wiley   +1 more source

Impact of time‐restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high‐fat diet‐induced obesity

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A 10 week time‐restricted feeding (TRF) regimen was implemented in aged female mice following 12 weeks of high‐fat diet (HFD) feeding. TRF partially reversed HFD‐induced weight and fat mass gain, reduced adipocyte size and increased size heterogeneity in white adipose tissue.
Theresa Bushman   +2 more
wiley   +1 more source

Spatio‐Temporal Diversity of Calcium Activity in Microglia

open access: yesGlia, Volume 74, Issue 3, March 2026.
Ca2+ activity mostly occurs in microglial processes and stays localized. When it spreads, it often shows a directional bias and is constrained by branch points. Activity strongly relies on P2Y12 receptors and is shaped by neuronal activity. ABSTRACT Microglia, the brain's innate immune cells, possess complex, highly motile branched processes. These act
Hiroshi Horiuchi   +3 more
wiley   +1 more source

Enhanced diagnostic accuracy of high‐grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis

open access: yesInternational Journal of Cancer, Volume 158, Issue 4, Page 1116-1125, 15 February 2026.
What's new? Cervical cancer screening is challenging in postmenopausal women, partly due to physiological changes that reduce the sensitivity of cytology and colposcopy. This study evaluated the diagnostic performance of combined PAX1 and JAM3 gene methylation testing in a large cohort of postmenopausal women undergoing colposcopy. Compared to cytology
Huanzi Peng   +11 more
wiley   +1 more source

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