Results 51 to 60 of about 7,008 (268)

A Statistical Learning Method for the Prediction of Anti-HIV Activity Using Topological Indices Based on Steiner Eccentricity

Journal of Applied Mathematics
The prediction of molecular activity plays an important role in drug discovery. Various approaches have been devised to predict anti-HIV activity based on topological indices.
Xingfu Li
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Degree-Distance Based Topological Indices of Crystal Cubic Carbon Structure

Atoms, 2018
Chemical graph theory comprehends the basic properties of an atomic graph. The sub-atomic diagrams are the graphs that are comprised of particles called vertices and the covalent bond between them are called edges.
Hong Yang, Muhammad Kamran Siddiqui, Misbah Arshad, Muhammad Naeem   +3 more
doaj   +1 more source

Reduction of gas bubbles and improved critical current density in Bi-2212 round wire by swaging

, 2013
Bi-2212 round wire is made by the powder-in-tube technique. An unavoidable property of powder-in-tube conductors is that there is about 30% void space in the as-drawn wire.
Di Michiel, Marco, Ghosh, Arup K., Hellstrom, Eric E., Hong, Seung, Huang, Yibing, Jiang, Jianyi, Larbalestier, David C., Miao, Hanping, Parrell, Jeff A., Scheuerlein, Christian, Trociewitz, Ulf P.   +10 more
core   +1 more source

Gain control from beyond the classical receptive field in primate primary visual cortex [PDF]

, 2003
Gain control is a salient feature of information processing throughout the visual system. Heeger (1991, 1992) described a mechanism that could underpin gain control in primary visual cortex (VI). According to this model, a neuron's response is normalized
Barraclough, N E, Derrington, A M, Parker, A, Tinsley, C J, Webb, B S   +4 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Primjene teorije grafova: topologijski modeli za predvi|anje CDK-1 inhibicijske aktivnosti aloizina [PDF]

, 2005
Relationship between the topological indices and cyclin-dependent kinase-1 (CDK-1/cyclin B) inhibitory activity of 6-phenyl[5H]pyrrolo[2,3-b]pyrazines (aloisines) was investigated.
Anil K. Madan, Viney Lather
core  

On the eccentric connectivity index of unicyclic graphs

, 2018
Summary: In this paper, we obtain the upper and lower bounds on the eccentricity connectivity index of unicyclic graphs with perfect matchings. Also, we give some lower bounds on the eccentric connectivity index of unicyclic graphs with given matching numbers.
Nacaroglu, Yasar, Maden, Ayse Dilek
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Eccentric harmonic index of a graph

Arab Journal of Basic and Applied Sciences, 2019
In this paper, we introduce the eccentric harmonic index of a graph G, so that it is the sum of the terms for the edges where ei is the eccentricity of the ith vertex of the graph G. We compute the exact values of He for some standard graphs.
M. I. Sowaity, M. Pavithra, B. Sharada, A. M. Naji   +3 more
doaj   +1 more source