Results 51 to 60 of about 1,059 (263)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

On the non-commuting graph of dihedral group

Electronic Journal of Graph Theory and Applications, 2020
For a nonabelian group G, the non-commuting graph Γ of G is defined as the graph with vertex-set G-Z(G), where Z(G) is the center of G, and two distinct vertices of Γ are adjacent if they do not commute in G.
Sanhan Muhammad Salih Khasraw, Ivan Dler Ali, Rashad Rashid Haji   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Statistical Learning Method for the Prediction of Anti-HIV Activity Using Topological Indices Based on Steiner Eccentricity

Journal of Applied Mathematics
The prediction of molecular activity plays an important role in drug discovery. Various approaches have been devised to predict anti-HIV activity based on topological indices.
Xingfu Li
doaj   +1 more source

Degree-Distance Based Topological Indices of Crystal Cubic Carbon Structure

Atoms, 2018
Chemical graph theory comprehends the basic properties of an atomic graph. The sub-atomic diagrams are the graphs that are comprised of particles called vertices and the covalent bond between them are called edges.
Hong Yang, Muhammad Kamran Siddiqui, Misbah Arshad, Muhammad Naeem   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Computing eccentric connectivity index of nanostar dendrimers

, 2017
Let G be a molecular graph, the eccentric connectivity index of G is defined as ξc(G) = Σu∈V(G)deg(u)·ecc(u), where deg(u) denotes the degree of vertex u and ecc(u) is the largest distance between u and any other vertex v of G, namely, eccentricity of u.
Ali Nejati, Sara Mehdipour, Mehdi Alaeiyan   +2 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Extremal results on the eccentric connectivity index [PDF]

, 2019
The eccentric connectivity index of a connected graph is the sum over all vertices of the product between eccentricity (maximum distance to any other vertex) and degree.
Hauweele, Pierre, Devillez, Gauvain, Hertz, Alain, Mélot, Hadrien, Ries, Bernard   +4 more
core  

Eccentric harmonic index of a graph

Arab Journal of Basic and Applied Sciences, 2019
In this paper, we introduce the eccentric harmonic index of a graph G, so that it is the sum of the terms for the edges where ei is the eccentricity of the ith vertex of the graph G. We compute the exact values of He for some standard graphs.
M. I. Sowaity, M. Pavithra, B. Sharada, A. M. Naji   +3 more
doaj   +1 more source