Results 201 to 210 of about 22,370 (258)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Acute Effects of Combined and Distinctive Stretching, Foam Rolling, and Eccentric Exercise in Young Men with Hamstring Tightness. [PDF]

J Hum Kinet
Kamandulis S, Werasirirat P, Namsawang J, Singhasoot N, Snieckus A, Muanjai P.   +5 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Effect of clove flower extract ( <b><i>Syzygium aromaticum</i></b> ) administration timing on skeletal muscle damage induced by eccentric exercise: An in vivo study. [PDF]

Narra J
Ningrum TS, Doewes M, Indarto D, Cilmiaty R, Kristiyanto A, Widyaningsih V.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Effects of Percussive Massage Treatments on Symptoms Associated with Eccentric Exercise-Induced Muscle Damage. [PDF]

J Sports Sci Med
Roberts TD, Costa PB, Lynn SK, Coburn JW.   +3 more
europepmc   +1 more source

Biceps brachii elastography in well-trained men post eccentric exercise-induced muscle damage. [PDF]

J Ultrasound
Brandão MCA, Matias LA, da Matta TT, de Oliveira LF.   +3 more
europepmc   +1 more source

Effect of eccentric exercise on plasma enzyme activities previously elevated by eccentric exercise

, 1995
openaire   +1 more source

Impact of Eccentric Exercise Interventions with Small and Large Ranges of Motion on Rat Skeletal Muscle Tissue and Muscle Force Production. [PDF]

Int J Mol Sci
Oga R, Nakagawa K, Chen YC, Nita Y, Tamaki H.   +4 more
europepmc   +1 more source