miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila
PLoS Pathogens, 2016 microRNAs are endogenous small regulatory RNAs that modulate myriad biological processes by repressing target gene expression in a sequence-specific manner.
Xiao-Peng Xiong +7 more
semanticscholar +1 more source
A Drosophila ecdysone-deficient model to assess the endocrine disruptor activity of Bisphenol A
Ecotoxicology and Environmental SafetyBisphenol A (BPA) is a well characterized endocrine disruptor that interferes with the activity of a variety of nuclear receptors. For this reason, BPA has the potential to impact the function of the endocrine system and alter cellular physiology.
Patricia Vega-Cuesta +8 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2004 The effects of blood components, nerve-cord severance, and ecdysone therapy on the posterior midgut epithelial cells of 5th-instar Rhodnius prolixus nymphs 10 days after feeding were analyzed by transmission electron microscopy. Cutting the nerve-cord of
JM Albuquerque-Cunha +6 more
doaj +1 more source
Use of Injectable Eugenol for Euthanasia and Anesthesia of American Lobsters (Homarus Americanus) and Similar Species [PDF]
, 2012 Crustaceans are economically and ecologically significant, but current treatment and diagnostic protocols for crustacean health are limited. According to standards given by the American Veterinary Medical Association there are no current methods of ...
Huntsberger, Carlton
core +1 more source
Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes [PDF]
, 2007 Background Transposons, i.e. transposable elements (TEs), are the major internal spontaneous mutation agents for the variability of eukaryotic genomes. To address the general issue of whether transposons mediate genomic changes in environment-adaptation ...
Song Chen, Xianchun Li
core +2 more sources
Structural diversity and evolution of the N-terminal isoform-specific region of ecdysone receptor-A and -B1 isoforms in insects [PDF]
, 2010 Background The ecdysone receptor (EcR) regulates various cellular responses to ecdysteroids during insect development. Insects have multiple EcR isoforms with different N-terminal A/B domains that contain the isoform-specific activation function (AF)-1 ...
Takayuki Watanabe +2 more
core +1 more source
Anopheles gambiae blood feeding Initiates an anticipatory defense response to plasmodium berghei
, 2014 Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pathogens. Much remains unknown about how different pathogens are sensed and specific responses triggered.
Christophides, GK +2 more
core +1 more source
Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT [PDF]
, 2020 Huntington’s disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates.
Agrawal, Namita +10 more
core
Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization [PDF]
, 2015 The use of time series profiling to identify groups of functionally related genes (synexpression groups) is a powerful approach for the discovery of gene function. Here we apply this strategy during RasV12 immortalization of Drosophila embryonic cells, a
Dequeant, M. L. +6 more
core +1 more source
The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in drosophila melanogaster through maintaining a progenitor-like cell state [PDF]
, 2016 The capacity of tumour cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal pathways. Using an epithelial cancer model in Drosophila melanogaster, we carried out an overexpression screen for ...
Aigaki, Toshiro +12 more
core +1 more source