Results 21 to 30 of about 26,814 (299)

Dual inhibition of the Echinococcus multilocularis energy metabolism

Frontiers in Veterinary Science, 2022
Alveolar echinococcosis is caused by the metacestode stage of the zoonotic parasite Echinococcus multilocularis. Current chemotherapeutic treatment options rely on benzimidazoles, which have limited curative capabilities and can cause severe side effects.
S. Chaudhry, R. Zurbriggen, M. Preza, Tobias Kämpfer, M. Kaethner, Roman Memedovski, Nathalie Scorrano, A. Hemphill, J. S. Doggett, B. Lundström-Stadelmann   +9 more
semanticscholar   +1 more source

Detection of Echinococcus multilocularis in carnivores in Razavi Khorasan province, Iran using mitochondrial DNA. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Echinococcus multilocularis is the source of alveolar echinococcosis, a potentially fatal zoonotic disease. This investigation assessed the presence of E.
Molouk Beiromvand, Lame Akhlaghi, Seyed Hossein Fattahi Massom, Iraj Mobedi, Ahmad Reza Meamar, Hormozd Oormazdi, Abbas Motevalian, Elham Razmjou   +7 more
doaj   +1 more source

Dual Role of Hepatic Macrophages in the Establishment of the Echinococcus multilocularis Metacestode in Mice

Frontiers in Immunology, 2021
Echinococcus multilocularis larvae, predominantly located in the liver, cause a tumor-like parasitic disease, alveolar echinococcosis (AE), that is characterized by increased infiltration of various immune cells, including macrophages, around the lesion ...
Hui Wang, Chuangshan Zhang, B. Fang, J. Hou, Wending Li, Zhide Li, Liang Li, Xiaojuan Bi, Liang Li, Abuduaini Abulizi, Y. Shao, R. Lin, H. Wen   +12 more
semanticscholar   +1 more source

Immunization with EmCRT-Induced Protective Immunity against Echinococcus multilocularis Infection in BALB/c Mice

Tropical Medicine and Infectious Disease, 2022
Alveolar echinococcosis (AE) is a severe parasitic zoonosis caused by the larval stage of Echinococcus multilocularis. The identification of the antigens eliciting acquired immunity during infection is important for vaccine development against ...
Lujuan Chen, Zhe Cheng, Siqi Xian, Bin Zhan, Zhijian Xu, Yan Yan, Jianfang Chen, Yanhai Wang, Limei Zhao   +8 more
doaj   +1 more source

In vivo and in vitro efficacy of crocin against Echinococcus multilocularis

Parasites & Vectors, 2021
Background Alveolar echinococcosis (AE) is a fatal zoonosis caused by the larvae of Echinococcus multilocularis . However, current chemotherapy treatment options are based on benzimidazoles [albendazole (ABZ) and mebendazole], which have limited efficacy.
Chuanchuan Liu, H. Fan, Lu Guan, R. Ge, Lan Ma   +4 more
semanticscholar   +1 more source

The situation of echinococcosis in stray dogs in Turkey: the first finding of Echinococcus multilocularis and Echinococcus ortleppi

Parasitology, 2021
Abstract Echinococcosis, caused by larval stage of the genus Echinococcus, is one of the most important zoonotic diseases worldwide. The purpose of this study was to determine the presence and prevalence of Echinococcus species in stray dogs of Erzurum ...
H. Avcioglu, E. Guven, I. Balkaya, Rıdvan Kirman, Muzaffer Akyuz, Mohammed Mebarek Bia, Hatice Gulbeyen, Sali Yaya   +7 more
semanticscholar   +1 more source

Asian Admixture in European Echinococcus multilocularis Populations: New Data From Poland Comparing EmsB Microsatellite Analyses and Mitochondrial Sequencing

Frontiers in Veterinary Science, 2021
The cestode Echinococcus multilocularis is the causative agent of a severe zoonotic disease: alveolar echinococcosis (AE). The parasite is distributed over a vast area in northern Eurasia and North America, but the impact of AE on human health is highly ...
G. Umhang, J. Knapp, M. Wassermann, Vanessa Bastid, C. Peytavin de Garam, F. Boué, T. Cencek, T. Romig, J. Karamon   +8 more
semanticscholar   +1 more source

Soil contamination by Echinococcus multilocularis in rural and urban vegetable gardens in relation to fox, cat and dog faecal deposits

Parasite, 2021
Echinococcus multilocularis eggs are deposited on the ground with the faeces of the carnivore definitive hosts. A reliable assessment of the spatial distribution of E.
Abdou Malik Da Silva, M. Bastien, G. Umhang, F. Boué, Vanessa Bastid, Jean-Marc Boucher, C. Caillot, C. P. de Garam, C. Renault, Marine Faisse, Sandra Courquet, Vincent Scalabrino, L. Millon, J. Knapp, M. Poulle   +14 more
semanticscholar   +1 more source

2-Deoxy-D-glucose and combined 2-Deoxy-D-glucose/albendazole exhibit therapeutic efficacy against Echinococcus granulosus protoscoleces and experimental alveolar echinococcosis.

PLoS Neglected Tropical Diseases, 2022
2-Deoxy-D-glucose (2-DG) is a glucose analog used as a promising anticancer agent. It exerts its effects by inhibiting the glycolytic energy metabolism to deplete cells of energy.
Qi Xin, Wei Lv, Yunxi Xu, Yumei Luo, Caifang Zhao, Bichen Wang, Miaomiao Yuan, Huanping Li, Xiaoxia Song, Tao Jing   +9 more
doaj   +1 more source

In vitro and in vivo efficacy of thiacloprid against Echinococcus multilocularis

Parasites & Vectors, 2021
Background Alveolar echinococcosis (AE) is a chronic zoonosis caused by the larval form of Echinococcus multilocularis ( E. multilocularis ). Current chemotherapy against AE has relied on albendazole and mebendazole, which only exhibit parasitostatic and
Chuanchuan Liu, H. Fan, Jie Ma, Lan Ma, R. Ge   +4 more
semanticscholar   +1 more source