Results 101 to 110 of about 317,020 (282)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Hierarchical Count Echo State Network Models with Application to Graduate Student Enrollments
Data Science in SciencePoisson autoregressive count models have evolved into a time series staple for correlated count data. This paper proposes an alternative to Poisson autoregressions: count echo state networks.
Qi Wang, Paul A. Parker, Robert Lund
doaj +1 more source
SDN as Active Measurement Infrastructure [PDF]
, 2017 Active measurements are integral to the operation and management of networks, and invaluable to supporting empirical network research. Unfortunately, it is often cost-prohibitive and logistically difficult to widely deploy measurement nodes, especially ...
Beverly, Robert, Rye, Erik
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Spiking Echo State Convolutional Neural Network for Robust Time Series Classification
IEEE Access, 2019 In this paper, a novel high-accuracy and robust computing framework for time series classification tasks is presented. The framework consists of a feature extraction module and a classification module, where the feature extraction is implemented by ...
Anguo Zhang, Wei Zhu, Juanyu Li
doaj +1 more source
Bidirectional deep-readout echo state networks
, 2018 We propose a deep architecture for the classification of multivariate time series. By means of a recurrent and untrained reservoir we generate a vectorial representation that embeds temporal relationships in the data.
Bianchi, Filippo Maria +3 more
core
System Identification of multi-rotor UAVs using echo state networks [PDF]
, 2015 Controller design for aircraft with unusual configurations presents unique challenges, particularly in extracting valid mathematical models of the MRUAVs behaviour.
Anderson, David +2 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source