Results 211 to 220 of about 115,894 (308)

Massive Pericardial Effusion as a Manifestation of Severe Autoimmune Hypothyroidism in an Adolescent With Down Syndrome: Importance of Early Recognition and Thyroid Hormone Replacement

open access: yesClinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT The clinical features of severe hypothyroidism may overlap with those of Down syndrome, delaying diagnosis until complications such as myxedema crisis and massive pericardial effusion develop. Regular thyroid function screening is essential, and hypothyroidism‐associated massive pericardial effusion can often be treated conservatively with ...
Bivek Mishra   +6 more
wiley   +1 more source

Sphingosine‐1‐Phosphate Attenuates LPS‐Induced Inflammatory Cardiac Injury in Association With RASGRP1–S100A9–NLRP3 Signaling

open access: yesDrug Development Research, Volume 87, Issue 7, November 2026.
ABSTRACT Lipopolysaccharide (LPS) induces endotoxemia‐associated inflammatory cardiac injury rather than classical viral or autoimmune myocarditis. Sphingosine‐1‐phosphate (S1P) regulates cardiovascular and immune responses, predominantly through S1P receptors, but whether it also modulates macrophage‐associated inflammatory signaling during LPS ...
Chaofu Yue   +15 more
wiley   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan   +23 more
wiley   +1 more source

Necrotic adrenal myelolipoma in a geriatric dog

open access: yesVeterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract Adrenal myelolipomas are rare in dogs and usually incidental findings. They appear as hyperechoic, heterogeneous masses on ultrasound and fat‑dominant lesions on computed tomography (CT). An 11‑year‑old Spaniel cross presented with a 2‑day history of diarrhoea, vomiting and polyuria/polydipsia.
Heather Durkin, Sophie Aspinall
wiley   +1 more source

Fulminant brachycephalic obstructive airway syndrome in a 3‐month‐old French bulldog

open access: yesVeterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 3‐month‐old, entire, female French bulldog (6.4 kg) presented in severe respiratory distress with hyperthermia and cyanosis. Laryngeal examination revealed severe obstruction by oedematous tissue, later confirmed as bilaterally everted laryngeal saccules; the airway was stabilised by tracheal intubation.
Yasumasa Iimori   +4 more
wiley   +1 more source

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