Results 111 to 120 of about 1,226 (208)

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, EarlyView.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer, Daniel Finke, Sebastian Romann, Norbert Frey, Joerg Heineke, Lorenz H. Lehmann   +5 more
wiley   +1 more source

Primary cardiac T‐cell rich large B‐cell lymphoma causing aortic stenosis with metastasis in a Warmblood

Equine Veterinary Education, EarlyView.
Summary An 18‐year‐old Warmblood mare was presented to the Royal Veterinary College Equine Referral Hospital for investigation of progressive periocular and facial swelling, weight loss and tachycardia. Physical examination additionally identified bilateral pansystolic (grade 5/6 basilar left‐sided, 2/6 right‐sided), cardiac murmurs, submandibular ...
S. E. Talbot, F. Z. X. Lean, H. M. Martineau, B. Dunkel, J. Reed   +4 more
wiley   +1 more source

Cardiac arrhythmia prevalence and risk factors in 24‐h electrocardiograms of sedentary horses

Equine Veterinary Journal, EarlyView.
Abstract Background Cardiac arrhythmias are common in horses, but their clinical relevance remains controversial. Objectives To describe prevalence and identify risk factors for arrhythmias that may warrant additional screening in a sedentary mixed‐breed population of horses. Study Design Prospective cross‐sectional.
Lauren T. Maas, Elizabeth Williams Louie, Carrie J. Finno, Callum G. Donnelly, Joshua A. Stern, Ashley E. Hill, Jessica M. Morgan   +6 more
wiley   +1 more source

Catheter Ablation: Evolution and Efficiencies

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT The present review includes a discussion the goals and pitfalls of efficiency in the medical profession, a historical perspective on the evolution of catheter ablation in the field of electrophysiology (EP), and the data regarding the relationship between efficiency and outcomes in the EP lab. Focus on efficacy is critical to maximize resource
Aravind G. Kalluri, Bradley P. Knight
wiley   +1 more source

Pulsed Field Versus Radiofrequency Ablation in Concomitant Pulmonary Vein Isolation and LAA Occlusion: Impact on Peridevice Leak and Procedural Efficiency

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Concomitant pulmonary vein isolation (PVI) and left atrial appendage occlusion (LAAO) is increasingly performed in patients with atrial fibrillation (AF) at elevated thromboembolic risk. Radiofrequency ablation (RFA) has been the conventional approach, but pulsed field ablation (PFA) may reduce tissue edema, procedural duration, and
Mohammad Montaser Atasi, Shea Hubbard, Charles Campbell, Charbel Noujaim, Christian M. Massad, Michel Abou Khalil, Yara Menassa, Alex El Darzi, Maximilian Moersdorf, Carlo El Khoury, Chanho Lim, Yingshuo Liu, Yishi Jia, Abboud Hassan, Mayana Bsoul, Ghassan Bidaoui, Hadi Younes, Monique Young, Bassam Wanna, Amitabh C. Pandey, Omar Kreidieh, Han Feng, Qussay Marashly, Nassir F. Marrouche   +23 more
wiley   +1 more source

Real‐Time 3D Mapping Corrects Fluoroscopic Misperception During Pulmonary Vein Isolation by Pulsed Field Ablation

Journal of Cardiovascular Electrophysiology, EarlyView.
In a three‐phase comparison (fluoroscopy‐only, 3D‐blinded, and real‐time 3D‐EAM), 23.8% of blinded procedures missed at least one pulmonary vein. Real‐time 3D mapping eliminated missed veins and reduced PVI applications. 3D‐EAM, three‐dimensional electroanatomical mapping; CT, computed tomography; LA, left atrium; PV, pulmonary vein.
Grégoire Massoullié, Saer Abu‐Alrub, Frederic Jean, Antoine Boudias, Pierre Antoine Catalan, Clément Riocreux, Bruno Pereira, Guillaume Clerfond, Romain Eschalier   +8 more
wiley   +1 more source

Pericardial Three-dimensional Echocardiography

Journal of Echocardiography, 2008
Ichige Kajimura, Gengi Satomi, Satoshi Yasukochi, Kiyohiro Takigiku, Yorikazu Harada, Shunji Uchita   +5 more
openaire   +2 more sources

Characterization of AV Nodal Left Inferior Extension by Use of High‐Density Mapping and Voltage‐Time Relationship

Journal of Cardiovascular Electrophysiology, EarlyView.
High resolution voltage LA map is shown with Ripple mapping during sinus rhythm prior to atrial fibrillation ablation (panel A‐D, top row Left Anterior Oblique view, bottom row Left Anterior Oblique Caudal view). Chamber activation is visualized by white Ripple bars, proceeding from the septum and septal roof (panel A), spreading clockwise and ...
June K. Pickett, Joshua R. Hirsch, Michael Charles C. Tan, Abdi Rasekh, Joanna E. Molina‐Razavi, Mehdi Razavi, Mihail G. Chelu, Payam Safavi‐Naeini, Mohammad Saeed   +8 more
wiley   +1 more source

Initial Pre‐Clinical Evaluation of the Augmented Ultra‐Low Temperature Cryoablation Catheter for Ventricular Ablations

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Ultra‐low Temperature Cryoablation (ULTC) using nitrogen cryogen near its boiling temperature of −196°C is a novel cardiac ablation modality capable of producing titratable lesions with depth exceeding 10 mm and has been recently introduced for catheter treatment of drug‐refractory ventricular tachycardia (VT). The ablative action
Katia Dyrda, Atul Verma, Borislav Dinov, Thomas Fink, Tom De Potter, Santi Raffa, Martin Sirois, Marie‐Elaine Clavet‐Lanthier, Ilya Grigorov, Pedram Pourfard, Alex Babkin, Vidal Essebag   +11 more
wiley   +1 more source