Results 121 to 130 of about 378,128 (332)

Bioprinted Micro‐Clots for Kinetic Analysis of Endothelial Cell‐Mediated Fibrinolysis

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper describes the development of a microscale model that quantifies the breakdown of fibrin by endothelial cells. The small size scale of this engineered system enables fibrin breakdown to be observed without the addition of external activators. This system could help in identifying compounds which both promote and hinder thrombosis.
Jonathan J. Chang   +5 more
wiley   +1 more source

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

open access: yesAdvanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche   +16 more
wiley   +1 more source

Colon‐Targeted Natural Polysaccharide‐Berberine Armored Hydrogel for the Treatment of Colitis

open access: yesAdvanced Healthcare Materials, EarlyView.
In this research, a novel hydrogel system targeting the colon is developed, incorporating Rhubarb polysaccharides and berberine‐loaded dendrimer. This hydrogel, forms through intermolecular hydrogen bonding and electrostatic interactions, accumulates in colonic tissues, effectively alleviating pathological immune hyperactivation while modulating gut ...
Miao Guo   +8 more
wiley   +1 more source

The Eclipse of Reason - A Present Time Risk

open access: yesAcademicus International Scientific Journal
This paper contends that technical progress, from automation in industry to artificial intelligence, might involve the risk of a humanly impoverished society. Instrumental values could overcome final values and determine the end of meaning.
Franco Ferrarotti
doaj   +1 more source

Eclipse of the Sun [PDF]

open access: yesAstronomische Nachrichten
n ...
openaire   +2 more sources

Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices

open access: yesAdvanced Healthcare Materials, EarlyView.
The covalent binding of dexamethasone to the surface of polyimide represents the electrically inert part of implantable intraneural devices. This ensures a sustained release of the drug for 9 weeks. In vitro and in vivo tests confirm the reduction of the foreign body reactions and the improved biocompatibility of dexamethasone functionalized polyimide.
Giulia Turrin   +19 more
wiley   +1 more source

Discovery of Eclipses from the Accreting Millisecond X-ray Pulsar SWIFT J1749.4-2807

open access: yes, 2010
We report the discovery of X-ray eclipses in the recently discovered accreting millisecond X-ray pulsar Swift J1749.4-2807. This is the first detection of X-ray eclipses in a system of this type and should enable a precise neutron star mass measurement ...
Altamirano   +22 more
core   +1 more source

The Solar Eclipse [PDF]

open access: yesNature, 1872
IT does not happen more than once in a lifetime to see such a glorious and magnificent sight as that from which I have just returned; that is, the total eclipse of the sun. I have seen many eclipses before, but never anything to equal this. I was engaged to go with the Morgans to the top of the hill to see it.
openaire   +2 more sources

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

open access: yesAdvanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun   +13 more
wiley   +1 more source

EclipseNB: A Network of Low‐Cost GNSS Receivers to Study the Ionosphere

open access: yesSpace Weather
This work aims to demonstrate that dense networks of low‐cost dual‐frequency global navigation satellite systems (GNSS) receivers can be used to retrieve ionospheric electron content with almost the same level of accuracy as scientific‐grade GNSS ...
A. Kashcheyev   +4 more
doaj   +1 more source

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