Results 51 to 60 of about 198,418 (346)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

The Response of the Ionosphere‐Thermosphere System to the 21 August 2017 Solar Eclipse

open access: yesJournal of Geophysical Research - Space Physics, 2019
We simulated the effects of the 21 August 2017 total solar eclipse on the ionosphere‐thermosphere system with the Global Ionosphere Thermosphere Model (GITM).
I. Cnossen   +3 more
semanticscholar   +1 more source

Biophysical modeling for accurate T cell specificity prediction of viral and tumor antigens

open access: yesNature Communications
We develop and apply a dual experimental and computational framework to predict antigen specificity of TCR sequences in serial clinical samples. Our model integrates TCR primary sequences with previously reported and in silico-derived TCR-pMHC structural
Zahra S. Ghoreyshi   +13 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Confirming Variability in the Secondary Eclipse Depth of the Super-Earth 55 Cancri e [PDF]

open access: yes, 2018
We present a reanalysis of five transit and eight eclipse observations of the ultrashort-period super-Earth 55 Cancri e observed using the Spitzer Space Telescope during 2011–2013.
P. Tamburo   +3 more
semanticscholar   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Mal tiempo en Bagdad: al-Ṭurṭūšī y el “eclipse” de 478/1085-1086

open access: yesAl-Qantara : Revista de Estudios Arabes, 2019
El artículo analiza un pasaje autobiográfico de la vida de al-Ṭurṭūšī (c. 451/1059-520/1126, o Ŷumādā al-awwal 525/abril de 1131) contenido en el Siyar A‘lām al-Nubalā’ de al-Ḏahabī (673/1274-748/1348).
David J. Wasserstein
doaj   +1 more source

Eclipse

open access: yes, 2019
Visualization 1: ‘Eclipse’ short animation demonstrating the spectral deconstruction using the MCMMF and deep learning ...
Otto Muskens (5351714)
core   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

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