Results 21 to 30 of about 102,583 (267)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Contribution of Citizen Science Data on the Evaluation of Local Biodiversity of Benthic Macroinvertebrate Communities

Ecologies
Citizen science is increasingly utilized for environmental monitoring and educational purposes. For lotic ecosystems, this approach could be used to implement traditional methods and gain more data on local biodiversity, particularly in areas where ...
Alessandro Lagrotteria, Samuele Roccatello, Alberto Doretto   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Policies and strategies on active and healthy ageing: a scoping review of the recommendations of European and international agencies

Frontiers in Public Health
BackgroundOver the past six decades, life expectancy has significantly increased, with a concurrent decline in fertility rates, leading to unprecedented demographic shifts.
Silvia Caristia, Erica Viola, Thellenxa Kalemi, Davide Servetti, Samuele Poy, Fabrizio Faggiano   +5 more
doaj   +1 more source

Education, Off-the-Job Vocational Training, and Early Employment Outcomes: Evidence from Italy

Merits, 2023
Education and training are primary sources of individual human capital. We explored the relationship between education and off-the-job vocational training and the impact of training programmes on youth employment in Italy.
Giorgia Casalone, Eliana Baici
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Revitalising abandoned historical districts. Application of an incremental and adaptive approach to regeneration

TeMA: Journal of Land Use, Mobility and Environment
Urban regeneration in historical contexts must integrate physical restoration with socio-economic revitalization. This study examines the regeneration of an abandoned area in Palermo’s historic centre, altered by degradation and marginalization ...
Diksha Dody, Daniele Ronsivalle, Maurizio Carta   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source