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Unveiling Endotypes in Systemic Lupus Erythematosus Through Multiomic Analysis: Insights Into Cardiovascular and Renal Complications

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source

Ted Talks como recurso docente en la asignatura de “Economics of social expenditure” del grado en Economía

Revista de Estudios Empresariales. Segunda Época
Objetivo: La pandemia puso de manifiesto la necesidad de reforzar otro tipo de métodos docentes como son la docencia virtual, la gamificación o los formatos asíncronos.
David Cantarero Prieto +3 more
doaj +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source

Análisis de costo-efectividad de nilotinib, dasatinib e imatinib como terapia de primera línea en leucemia mieloide crónica en Colombia, 2012

Biomédica: revista del Instituto Nacional de Salud, 2014
Introducción. Los nuevos inhibidores de la tirosina cinasa para tratar la leucemia mieloide crónica basados en nilotinib, dasatinib e imatinib, mejoraron la calidad de vida de los pacientes y la tornaron en enfermedad crónica. Objetivo. Evaluar el costo-
Martín Romero +3 more
doaj +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera +15 more
wiley +1 more source

Stabilization Strategies for Carbon Based Perovskite Solar Cells Under Light, Heat, and Humidity

EcoEnergy, EarlyView.
Carbon‐based MA1−x(AVA)xPbI3/CsPbBr3 QD heterostructures fabricated under ambient conditions exhibit < 5% loss under ISOS‐D‐3 and reversible photo‐induced degradation, revealing the dual role of QDs in defect passivation and dynamic interfacial stabilization.
Emilie Planes +4 more
wiley +1 more source

Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe +15 more
wiley +1 more source

NKX2‐1 Downstream Regulatory Structural Variants Explain a Substantial Proportion of Molecular Diagnoses in Patients With Benign Hereditary Chorea

Movement Disorders, EarlyView.
Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard +33 more
wiley +1 more source

The Psychometric Properties of the Caregiver Feeding Style Questionnaire: A Cross‐Cultural Validation in Spanish Parents

Research in Nursing &Health, EarlyView.
ABSTRACT Parental feeding styles are a key dimension of parent‐child interactions during mealtimes and have a significant influence on children's development. Through their impact on children's eating behaviours, these styles are a key focus for enhancing the well‐being of both the child and the family as a whole.
Mar Lozano‐Casanova +5 more
wiley +1 more source

public aspects of medicine
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