The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova +12 more
wiley +1 more source
Beyond Structure: The Role of the Outer Integument in Embryo, Endosperm, and Seed Development in Annona. [PDF]
Garcia-Lezama M +4 more
europepmc +1 more source
Economia circular como princípio jurídico : uma perspetiva luso-brasileira
A presente pesquisa analisa a perspetiva de resposta jurídica à necessidade de mudança no atual modelo de sistema económico. Ao início apresenta o conceito de economia circular, a doutrina económica e os aspetos da transição para a economia circular na ...
Novelli, Gabriel Artur Amorim
core
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero +8 more
wiley +1 more source
Evaluating composted sewage sludge as a phosphorus fertilizer in wheat grown on soils with different properties. [PDF]
Guerrero-Gallardo L +7 more
europepmc +1 more source
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley +1 more source
Symbolic dimensions of health economics: connections with nursing work in hospitals. [PDF]
Carneiro ADPR +5 more
europepmc +1 more source
How to Study Family Learning Practices Mediated by Digital Platforms: A Scoping Review
ABSTRACT The dynamic and personalized nature of today's media ecosystem complicates the documentation and analysis of digital home learning environments. In response, innovative research methods have emerged, which we broadly categorize as passive (e.g., quantitative studies) or active participatory methods.
Moises Esteban‐Guitart +3 more
wiley +1 more source
Pharmaceutical Stability of Romiplostim: In-use Functional Study Using Microscale Thermophoresis New Strategy and Elisa. [PDF]
Hermosilla J +6 more
europepmc +1 more source
Artificial Intelligence in Climate and Sustainable Finance: A Blessing or a Curse?
ABSTRACT While there are concerns regarding the sustainability of artificial intelligence (AI), it is a potential ally in the transition toward a greener future. It offers advanced tools for data analysis; risk modeling; and environmental, social, and governance (ESG) assessment.
Filippo di Pietro +3 more
wiley +1 more source

