Results 191 to 200 of about 978,739 (277)

Economia circular na sociedade 4.0

open access: yes, 2020
Ercilia de Stefano   +4 more
openaire   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, Volume 20, Issue 11, Page 2674-2698, November 2026.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

open access: yesAdvanced Science, Volume 13, Issue 61, 3 November 2026.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias   +23 more
wiley   +1 more source

[Inhaled Respiratory Therapy and Global Warming]. [PDF]

open access: yesFarm Comunitarios
Casanova-Martínez C   +4 more
europepmc   +1 more source

When Teeth Twist: Distinct Mechanisms and Patterns of Enamel Wear from Rotational Forces—A Preliminary Investigation

open access: yesAmerican Journal of Biological Anthropology, Volume 191, Issue 3, November 2026.
ABSTRACT Motivation Dental enamel possesses a unique anisotropic, heterogeneous hierarchical structure which enables a combination of high hardness and remarkable durability compared to other natural and synthetic biomaterials. Nevertheless, it undergoes mechanical degradation through fracture from concentrated overloads and/or progressive wear, both ...
Estíbaliz Sánchez‐González   +5 more
wiley   +1 more source

Effects of intermittent exposure to hypobaria and cold on the microarchitecture and morphofunctional profile of rat gastrocnemius muscle

open access: yesThe Anatomical Record, Volume 309, Issue 11, Page 3330-3344, November 2026.
Abstract Intermittent hypobaric hypoxia (IHH) enhances oxygen transport, muscle metabolism, and cardiovascular health; however, the combined effects of hypobaria and cold are less well understood. Exposure to these stressful environmental factors, even intermittently, can affect skeletal muscle due to its plasticity, thereby altering its metabolic and ...
Garoa Santocildes   +3 more
wiley   +1 more source

Strain and Chirality: Catalytic Asymmetric Synthesis of Planar Chiral [2.2]Paracyclophanes

open access: yesChemistryEurope, Volume 4, Issue 11, November 2026.
Catalytic asymmetric synthesis is transforming access to planar‐chiral [2.2]paracyclophanes. This Review highlights recent advances in catalytic desymmetrization and asymmetric functionalization, emphasizing how catalyst design and PCP geometry govern reactivity and stereocontrol.
Daniel Alonso   +2 more
wiley   +1 more source

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