Results 31 to 40 of about 554,830 (233)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Convergent validity, reliability and responsiveness of the AP-7D and EQ-5D-5L based on the survey for the general people in five countries: a new cultural-specific preference-based measure developed in east and southeast asia

Health and Quality of Life Outcomes
Background The AP-7D is a preference-based measure that was recently developed for use in East and Southeast Asia. This study investigated the reliability and convergent validity of the new instrument.
Yuta Suzuki, Takeru Shiroiwa, Tatsunori Murata, Emi Kamono, Yasuhiro Morii, Takashi Fukuda   +5 more
doaj   +1 more source

Direct and indirect costs of cluster headache: a prospective analysis in a tertiary level headache centre

The Journal of Headache and Pain, 2020
Background Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (ECH) or chronic cluster headache (CCH) causing significant burden of disease and requiring attack therapy and prophylactic treatment.
Andrea Negro, Paolo Sciattella, Valerio Spuntarelli, Paolo Martelletti, Francesco Saverio Mennini   +4 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Effectiveness, costs and cost-effectiveness of chiropractic care and physiotherapy compared with information and advice in the treatment of non-specific chronic low back pain: study protocol for a randomised controlled trial

Trials, 2017
Background Low back pain is a global public health problem and a leading cause of disability all over the world. The lifetime prevalence of low back pain is 70–80% and a significant proportion of people affected develop chronic low back pain (CLBP ...
Filip Gedin, Martin Skeppholm, Kristina Burström, Vibeke Sparring, Mesfin Tessma, Niklas Zethraeus   +5 more
doaj   +1 more source

Development of a Model for Quantitative Assessment of Newborn Screening in Japan Using the Analytic Hierarchy Process

International Journal of Neonatal Screening, 2023
Whether or not conditions should be included in publicly funded newborn screening (NBS) programs should be discussed according to objective and transparent criteria. Certain criteria have been developed for the introduction of NBS programs in the context
Keiko Konomura, Eri Hoshino, Kotomi Sakai, Takashi Fukuda, Go Tajima   +4 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Platform Technology in Global Vaccine Regulation: Development, Applications, and Regulatory Strategies with Insights from China

Vaccines
The concept of “platform technology” gained prominence after the Ebola outbreak and since then has become essential to international vaccine (prophylactic vaccines against infectious disease) regulatory frameworks.
Xiaojing Li, Su Jin, Shuyang Guo, Dan Yang, Wenbo Sai, Xiao Qiu, Xin Zhao, Lan Wang, Tao Wang, Min Li   +9 more
doaj   +1 more source

Probabilistic cost-effectiveness analysis of controlled ovarian stimulation with recombinant FSH plus recombinant LH vs. human menopausal gonadotropin for women undergoing IVF

Reproductive Biology and Endocrinology, 2018
Background The association of recombinant FSH plus recombinant LH in 2:1 ratio may be used not only to induce ovulation in anovulatory women with hypogonadotropic hypogonadism but also to achieve multiple follicular developments in human IVF.
F. S. Mennini, A. Marcellusi, R. Viti, C. Bini, A. Carosso, A. Revelli, C. Benedetto   +6 more
doaj   +1 more source

Mapping EORTC QLQ-C30 and FACT-G onto EQ-5D-5L index for patients with cancer

Health and Quality of Life Outcomes, 2020
Background To develop direct and indirect (response) mapping algorithms from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and the Functional Assessment of Cancer Therapy General ...
Yasuhiro Hagiwara, Takeru Shiroiwa, Naruto Taira, Takuya Kawahara, Keiko Konomura, Shinichi Noto, Takashi Fukuda, Kojiro Shimozuma   +7 more
doaj   +1 more source