Results 41 to 50 of about 290,031 (289)
INCREASE THE IMPACT OF EUROPEAN FUNDS ON ROMANIAN RURAL DEVELOPMENT THROUGH VERNACULAR EXPERTISE
Economy and Sociology, 2022 It is well known that the projects financed by the European Union generate effects on the entities that implement them, on the interested factors, but also on the regions where they are implemented.
Cristina Copaceanu, Silvia Mazare
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Economy and Sociology, 2023 Premature mortality is a highly intricate concept, and despite its extensive exploration in specialized literature, a universally agreed-upon definition remains elusive.
Irina Pahomii
doaj +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
LONGITUDINAL METHOD APPROACH IN ASSESSING THE MOLDOVAN MIGRANTS’ STOCK
Economy and Sociology, 2023 Estimating international migration is a challenging exercise despite the information technologies used, regular censuses conducted, and available advanced administrative systems in collecting data on vital events.
Vitalie Ștîrba, Andrei Crivenco
doaj +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
INSIGHTS INTO THE DEMOGRAPHIC DIVIDEND AND THE WINDOW OF OPPORTUNITY: A CONCEPTUAL OVERVIEW
Economy and Sociology, 2023 The demographic dividend presents the conceptual framework through which changes in the population's age structure positively affect economic development.
Elena Șoldan
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
ANALYSIS OF FINANCIAL ASSISTANCE FROM INTERNATIONAL FINANCIAL INSTITUTIONS OF MOLDOVA
Economy and Sociology, 2022 The article considers the financial assistance of international financial institutions (the International Monetary Fund and the World Bank) to Moldova in their partnership process.
Sergey Stupachev
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source