Precision therapies for genetic epilepsies in 2025: Promises and pitfalls
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang +3 more
wiley +1 more source
Dung Beetle with Reflection Cuckoo Catfish Optimizer for Numerical Optimization and Reservoir Production Optimization. [PDF]
Li S, Yin T.
europepmc +1 more source
Caring Flexibly? Working Conditions and the Supply of Adult Care
ABSTRACT Although flexible employment policies can help employed individuals balance caregiving and paid work, limited evidence has been devoted to examining the effect of working flexibly on the supply of care to older adults. In this paper, we study the impact of flexible working conditions on the supply of informal adult care and mental health.
Joan Costa‐Font, Wanying Wang
wiley +1 more source
Comprehensive Learning-Enhanced Educational Competition Optimizer for Numerical Optimization and Reservoir Production Optimization. [PDF]
Li S, Luo J.
europepmc +1 more source
ABSTRACT With the increasing adoption of Artificial Intelligence (AI) in the workplace, employees' career paths have become more diverse and less predictable in the era of Industry 4.0. As technological transformations accelerate, employee turnover patterns are also changing, as reflected in the growing prevalence of occupational transitions and large ...
Young‐Kook Moon, Tanya Mitropoulos
wiley +1 more source
Defying the economic odds: vocational recovery as a clinical imperative in severe mental disorders. [PDF]
Byeon H.
europepmc +1 more source
ABSTRACT Soil salinization is a critical threat, impacting 20% of the world's irrigated lands and jeopardizing food security. In Ethiopia's Mirab Abaya district of the Gamo Zone, unsustainable irrigation methods exacerbate this issue. This paper examines local farmers' soil–water management systems and their awareness of salinization, aiming to educate
Oloba Jobe +3 more
wiley +1 more source
Safer at school? Experiences of families on school closure during COVID-19 in an informal settlement in Nairobi, Kenya. [PDF]
Echoka E +4 more
europepmc +1 more source
Navigating Parallel Careers: Profiles and Career Sustainability
ABSTRACT This study explores protean and boundaryless career profiles among parallel career track (PCT) holders, who are professionals who voluntarily maintain more than one career role simultaneously, and examines their relationship with sustainable career outcomes.
Maria Candida Baumer de Azevedo +3 more
wiley +1 more source
A Bio-Inspired Comprehensive Learning Strategy-Enhanced Parrot Optimizer: Performance Evaluation and Application to Reservoir Production Optimization. [PDF]
Yu B, Zhang Y.
europepmc +1 more source

