Results 51 to 60 of about 5,235,479 (357)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Statistical design approach enables optimised mechanical lysis for enhanced long-read soil metagenomics

Scientific Reports
Metagenomic analysis has enabled insights into soil community structure and dynamics. Long-read sequencing for metagenomics can enhance microbial ecology by improving taxonomic classification, genome assembly, and functional annotation.
Daniel G. Barber, Harry T. Child, Gabrielle R. Joslin, Lucy Wierzbicki, Richard K. Tennant   +4 more
doaj   +1 more source

Economic effects of dried blueberry production [PDF]

Journal on Processing and Energy in Agriculture, 2018
This paper analyses various aspects of the cost-effectiveness of dried blueberry production. The drying performed was convective using straw as the main source of heat.
Vukoje Veljko, Pavkov Ivan, Stamenković Zoran, Miljatović Aleksandar   +3 more
doaj   +1 more source

Vocational Rehabilitation and Employment of People With Disabilities: Report of a European Conference [PDF]

, 2004
[From Overview] The European Conference on Vocational Rehabilitation and Employment of Persons with Disabilities was held in Warsaw, Poland, on 23-25 October 2003.
International Labour Organization, Republic of Poland, Ministry of Economy, Labour and Social Policy   +1 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Green Economy: Regional Priorities [PDF]

, 2015
The article is dedicated to transforming the economy of Russian regions to a green economy, which is an essential factor for the sustainable development.
Bobylev, S. N., Kudryavtseva, O. V., Yakovleva, Ye. Yu.   +2 more
core   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

People Skills in the 21st Century: A Perspective on the Smart City in an Emerging Economy

Human Behavior and Emerging Technologies
Smart cities are hubs of innovation and rapid development, where technology plays a significant role in shaping the urban environment. In such settings, the ability to adapt and think flexibly is crucial for individuals to thrive.
Tanatorn Tanantong, Papon Moolngearn, Tanpat Kraiwanit, Pongsakorn Limna, Aishath Rafiyya   +4 more
doaj   +1 more source