Results 121 to 130 of about 225,565 (329)

An mTOR‐Tfeb‐Fabp7a Axis Ameliorates bag3 Cardiomyopathy via Decelerating Cardiac Aging

open access: yesAging Cell, EarlyView.
This study uncovered accelerated cardiac senescence as a key pathological event in bag3 cardiomyopathy, and reveals that manipulating the mTOR‐Tfeb‐Fabp7a axis can mitigate this pathology and confer cardioprotective effects. ABSTRACT While BAG3 has been identified as a causative gene for dilated cardiomyopathy, the major pathological events in BAG3 ...
Yonghe Ding   +7 more
wiley   +1 more source

Construcción de una genoteca de cDNA de fríjol (Phaseolus vulgaris L.) para mapeo genético

open access: yesActa Agronómica, 1995
<p>A small cDNA library from beans (Phaseolus vulgaris L.) of about 1500 clones was constructed, to further saturate the bean RFLP linkage map. The primarily synthesized cDNAs were amplified by PCR using the adaptors as primers for amplification ...
Roca William M.   +4 more
doaj  

Aging Reduces Intestinal Stem Cell Activity in Killifish and Intermittent Fasting Reverses Intestinal Gene Expression Patterns

open access: yesAging Cell, EarlyView.
Intestinal stem cells occur in clusters, and the cycle time of stem cells increases with age. The age‐dependent decline in structural intestinal tissue homeostasis is associated with a decline in stem cell activity. Aging causes significant changes in intestinal gene expression; intermittent fasting from adulthood onwards results in a gene expression ...
Michael Kothmayer   +12 more
wiley   +1 more source

Use of the KlADH4 promoter for ethanol-dependent production of recombinant human serum albumine in Kluyveromyces lactis [PDF]

open access: yes, 1999
KlADH4 is a gene of Kluyveromyces lactis encoding a mitochondrial alcohol dehydrogenase activity which is specifically induced by ethanol. The promoter of this gene was used for the expression of heterologous proteins in K.
CRISA A.   +6 more
core  

EcoRI cleavage sites in the argECBH region of the Escherichia coli chromosome [PDF]

open access: bronze, 1977
E.A. Devine   +4 more
openalex   +1 more source

ER Stress Ire1‐Xbp1s Pathway Maintains Youthful Epidermal Basal Layer Through the Regulation of Cell Proliferation

open access: yesAging Cell, EarlyView.
In young epidermal basal layer, the Ire1‐Xbp1s endoplasmic reticulum (ER) stress‐response pathway maintains cell proliferation by activating the cell cycle regulator Vcp, whereas the age‐dependent decline in glucose metabolism reduces Ire1‐Xbp1s activity, consequently downregulating cell proliferation.
Daniel Semmy   +10 more
wiley   +1 more source

Evidences for balancing selection from PAH-BglII and PAH-EcoRI polymorphisms in Isfahan population

open access: yesتاکسونومی و بیوسیستماتیک, 2010
Two polymorphic markers including BglII and EcoRI, were identified at intron 1 and intron 5 of PAH gene. In order to test whether these polymorphisms are behaving as neutral alleles or are being subjected to selective pressures in Isfahan population, 110
Zahra Fazeli Attar   +1 more
doaj  

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

open access: yesAndrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos   +4 more
wiley   +1 more source

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