Results 191 to 200 of about 227,914 (337)

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

Modification of Deoxyribonucleic Acid with Indole-Linked Nucleotides Induces BZ- and Z‑Conformation and Alters Its Sensitivity to Enzymatic Cleavage. [PDF]

ACS Omega
Lingala S, Fisiuk A, Stephen M, Mohanrao R, Klingsberg J, Vecchioni S, Volvovitz ES, Rozhkov S, Mallikaratchy P.   +8 more
europepmc   +1 more source

A partial map of the circular mitochondrial genome of Drosophila melanogaster. Location of EcoRI-sensitive sites and the adenine-thymine-rich region. [PDF]

, 1976
David R. Wolstenholme, Christiane M.‐R. Fauron   +1 more
openalex   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Loss of the vitellogenins confers a fitness disadvantage but does not impact brood size in <i>C. elegans</i>. [PDF]

MicroPubl Biol
Macharios MM, Hernandez YD, Breen PC, Dowen RH.   +3 more
europepmc   +1 more source

Presence of an allelic EcoRI restriction fragment of the c-mos locus in leukocyte and tumor cell DNAs of breast cancer patients.

, 1985
Rosette Lidereau, D Mathieu-Mahul, Charles Theillet, Marie‐Claude Renaud, M Mauchauffé, J Gest, Christian‐Jacques Larsen   +6 more
openalex   +2 more sources

PHR‐Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong, Shuman Wang, Chao Liu, Lulu Qiao, Kai Liu, Qiongli Jin, Xiaorong Mo, Xingxing Shen, Keke Yi, Zhiye Wang   +9 more
wiley   +1 more source

Genome-wide association studies on body-weight and body-size traits among Zhedong white geese based on a modified genotyping-by-sequencing method. [PDF]

BMC Genomics
Yang Y, Zhai S, Liu H, Wang H, He D.
europepmc   +1 more source

In Situ Engineering of Tumor Cells as Self‐Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy

Advanced Science, Volume 13, Issue 4, 19 January 2026.
The fused EV platform AS16‐EL@MPLA/p‐FX reprograms tumor cells into cytokine‐producing factories that continuously secrete XCL1 and FLT3L to recruit and differentiate cDC1s, while embedded MPLA activates them through TLR4 signaling and AS16 prevents their exhaustion, thereby enhancing antitumor immunity and establishing durable immune memory against ...
Shuiling Jin, Xiaoxi Wang, Bingyu Li, Xueqin Zhu, Zimai Liu, Jiao Lu, Yuanyuan Wei, Zixian Wu, Kai Li, Tiantian Zhang, Zonghong He, Pingping Zhu, Yuanming Qi, Benyu Liu, Hui Liu, Yongchao Wang, Zhenzhen Chen   +16 more
wiley   +1 more source

Novel <i>SSR4</i> gene splice variant leads to congenital disorder of glycosylation, type Iy. [PDF]

Front Pediatr
Li N, Chen C.
europepmc   +1 more source