Results 201 to 210 of about 165,447 (318)

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, Volume 12, Issue 23, June 20, 2025.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

The yeast CST and Polα/primase complexes act in concert to ensure proper telomere maintenance and protection. [PDF]

Nucleic Acids Res
Calugaru K, Yu EY, Huang S, González-Rodríguez N, Coloma J, Lue NF.   +5 more
europepmc   +1 more source

Use of the Restriction Enzyme EcoRI for Pulsed-Field Gel Electrophoretic Analysis of Helicobacter pylori

, 2005
Yoshio Hosaka, Kazuhiko Irinoda, Ryuichi Nakano, S Tanabe, Wasaburo Koizumi, Katunori Saigenji, Matsuhisa Inoue   +6 more
openalex   +1 more source

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source

Genetic and Epigenetic Diversity of <i>Pinus pinea</i> L.: Conservation Implications for Priority Populations in Greece. [PDF]

Genes (Basel)
Avramidou EV, Malliarou E, Korakaki E, Mantakas G, Kaoukis K.   +4 more
europepmc   +1 more source

Engineering an Overflow‐Responsive Regulation System for Balancing Cellular Redox and Optimizing Microbial Production

Biotechnology and Bioengineering, Volume 122, Issue 6, Page 1561-1573, June 2025.
ABSTRACT Escherichia coli accumulates acetate as a byproduct in fast growth aerobic conditions when using glucose as carbon source. This phenomenon, known as overflow metabolism, has negative impacts on cell growth and protein expression, also causes carbon loss during biosynthesis in most microbial production scenarios. In this study, we regarded the “
Jianli Zhang, Jian Wang, Tian Jiang, Xinyu Gong, Qi Gan, Yuxi Teng, Yusong Zou, Ainoor Anwar Dawadi, Yajun Yan   +8 more
wiley   +1 more source

A toolkit for facilitating markerless integration of expression cassettes in Komagataella phaffii via CRISPR/Cas9. [PDF]

Microb Cell Fact
García-Calvo L, Kummen C, Rustad S, Rønning SB, Fagerlund A.   +4 more
europepmc   +1 more source

Structural and Thermodynamic Basis for Enhanced DNA Binding by a Promiscuous Mutant EcoRI Endonuclease

, 2007
Paul J. Sapienza, John M. Rosenberg, Linda Jen‐Jacobson   +2 more
openalex   +2 more sources

"Ultraviolet footprinting" accurately maps sequence-specific contacts and DNA kinking in the EcoRI endonuclease-DNA complex. [PDF]

, 1988
M M Becker, David Lesser, Michael R. Kurpiewski, Alain Baranger, Linda Jen‐Jacobson   +4 more
openalex   +1 more source

EcoRI restriction endonuclease map of the composite R plasmid NR1

Journal of Bacteriology, 1976
N. Tanak, J. H. Cramer, R. Rownd
semanticscholar   +1 more source