Results 51 to 60 of about 165,447 (318)

Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B

Advanced Science, EarlyView.
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang, Cong Sun, Chu Xie, Bing‐Zhen Cheng, Zheng‐Zhou Lu, Ge‐Xin Zhao, Sen‐Fang Sui, Mu‐Sheng Zeng, Zheng Liu   +8 more
wiley   +1 more source

ISOLATION AND SEQUENCING OF A GENOMIC DNA ENCODING FOR ASCORBATE OXIDASE, A KEY ENZYME INVOLVED IN THE BIODEGRADATION OF ASCORBIC ACID IN MELON [PDF]

Journal of Central European Agriculture, 2002
A melon genomic library was used to isolate and characterize a clone of genomic DNA coding for ascorbate oxidase (AO) which is considered a key enzyme in the biodegradation of ascorbic acid (AA).
Evangelos ALATSATIANOS, Marin ARDELEAN, Constantin BOTEZ, Mircea SAVATTI, Radu SESTRAŞ, Mirela CORDEA   +5 more
doaj  

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Association between EcoRI fragment-length polymorphism of the immunoglobulin lambda variable 8 (IGLV8) gene family with rheumatoid arthritis and systemic lupus erythematosus

Brazilian Journal of Medical and Biological Research, 2001
The human immunoglobulin lambda variable 8 (IGLV8) subgroup is a gene family containing three members, one of them included in a monomorphic 3.7-kb EcoRI genomic fragment located at the major lambda variable locus on chromosome 22q11.1 (gene IGLV8a, EMBL
Queiroz R.G.P., Tamia-Ferreira M.C., Carvalho I.F., Petean F.C., Passos G.A.S.   +4 more
doaj  

MOLECULAR GENOTYPING OF RUMEN FUNGI BASED ON RFLP ANALYSIS

Acta Agriculturae Slovenica, 1998
Eight polycentric strains of the genera Orpinomyces and five monocentric strains of the genera Neocallimastix were examined for the restriction fragment length polymorphisms. EcoRI-digested nuclear DNA of isolates of rumen fungi and DNA-DNA hybridization
Kateřina FLIEGEROVÁ, Sylva PAŽOUTOVÁ, Blanka HODROVÁ   +2 more
doaj   +1 more source

Salt Effects on Protein-DNA Interactions: The λcI Repressor and EcoRI Endonuclease

, 1994
In this paper, finite-difference solutions to the nonlinear Poisson-Boltzmann (NLPB) equation are used to calculate the salt dependent contribution to the electrostatic DNA binding free energy for both the λcI repressor and the EcoRI endonuclease.
V. Misra, J. Hecht, K. Sharp, R. Friedman, B. Honig   +4 more
semanticscholar   +1 more source

CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

Advanced Science, EarlyView.
This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu, Haorui Luo, Jiahao Wang, Haifeng Liu, Luonan Chen, Hongbin Ji, Zimu Deng, Xiaolong Liu   +7 more
wiley   +1 more source

Use of AFLP marker system on sugarcane somaclones to study their resistance to rust

Biotecnología Vegetal, 2002
AFLPs (amplified fragment length polymorphism) was carried out from genomic DNA of five rust resistant sugar cane somaclons and their susceptible donor, Saccharum officinarum var B 4362, using three combinations of primers (EcoRI/aca: MseI/acc; EcoRI/aca:
María Ileana Oloriz, Luis Rojas, Víctor Gil, Milady Mendoza, Ariel Arencibia, Elva Rosa Carmona, Elio Jiménez   +6 more
doaj  

8-Oxoguanine Affects DNA Backbone Conformation in the EcoRI Recognition Site and Inhibits Its Cleavage by the Enzyme.

PLoS ONE, 2016
8-oxoguanine is one of the most abundant and impactful oxidative DNA lesions. However, the reasons underlying its effects, especially those not directly explained by the altered base pairing ability, are poorly understood.
Joanna J Hoppins, David R Gruber, Heather L Miears, Alexey S Kiryutin, Rustem D Kasymov, Darya V Petrova, Anton V Endutkin, Alexander V Popov, Alexandra V Yurkovskaya, Stanislav O Fedechkin, Jacob A Brockerman, Dmitry O Zharkov, Serge L Smirnov   +12 more
doaj   +1 more source

Verifikasi cDNA T29 sebagai kandidat gen pengkode protein Toxoplasma gondii dengan metode SDS PAGE

Journal of Biological Researches, 2012
The process of cDNA construction from mRNA isolated from Toxoplasma gondii has been done. There were 7 candidates cDNA which one of them is called T29.
Ira Djajanegara, Wayan Artama, Retno Lestari, Sabar Pambudi   +3 more
doaj   +1 more source