Results 71 to 80 of about 223,024 (272)

New Insights into Genotype-phenotype Correlations in Chinese Facioscapulohumeral Muscular Dystrophy: A Retrospective Analysis of 178 Patients

open access: yesChinese Medical Journal, 2015
Background: Facioscapulohumeral muscular dystrophy (FSHD), a common autosomal dominant muscular disorder, is caused by contraction of the D4Z4 repeats on 4q35.
Feng Lin   +4 more
doaj   +1 more source

Different fates of the chloroplast tufA gene following its transfer to the nucleus in green algae [PDF]

open access: yes, 1990
Previous work suggested that the tufA gene, encoding protein synthesis elongation factor Tu, was transferred from the chloroplast to the nucleus within the green algal lineage giving rise to land plants.
Baldauf, S.L.   +2 more
core   +4 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu   +13 more
wiley   +1 more source

Caracterización fenotípica y molecular de poblaciones de zacate punta blanca (Digitaria californica (Benth.) Henr.)

open access: yesRevista Mexicana de Ciencias Pecuarias, 2012
Se exploró y caracterizó la diversidad fenotípica y genotípica de poblaciones del pasto punta blanca [Digitaria californica (Benth.) Henr.], en pastizales de Chihuahua. Se realizó análisis de componentes principales y conglomerados.
Carlos Raúl Morales Nieto   +4 more
doaj  

Analysis of DNA methylation in various swine tissues. [PDF]

open access: yesPLoS ONE, 2011
DNA methylation is known to play an important role in regulating gene expression during biological development and tissue differentiation in eukaryotes. In this study, we used the fluorescence-labeled methylation-sensitive amplified polymorphism (F-MSAP)
Chun Yang   +7 more
doaj   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

open access: yesAdvanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob   +12 more
wiley   +1 more source

Modification of recombinant human epidermal growth factor (rh-EGF) expression vector by site-directed mutagenesis for therapeutic protein production

open access: yesIndonesian Journal of Biotechnology, 2019
Recombinant human epidermal growth factor (rh-EGF) has high value in therapies for h-EGF deficiency-related diseases. The expression of the h-EGF gene was designed by using the pET21b(+) vector and Escherichia coli BL21(DE3) as the expression host.
Achmad Rodiansyah   +3 more
doaj   +1 more source

Molecular cloning and characterization of a new member of the gap junction gene family, connexin-31 [PDF]

open access: yes, 1991
A new member of the connexin gene family has been identified and designated rat connexin-31 (Cx31) based on its predicted molecular mass of 30,960 daltons. Cx31 is 270 amino acids long and is coded for by a single copy gene.
Hoh, Jan H.   +2 more
core  

ER5, a tomato cDNA encoding an ethylene-responsive LEA-like protein: characterization and expression in response to drought, ABA and wounding [PDF]

open access: yes, 1997
We report the isolation by differential display of a novel tomato ethylene-responsive cDNA, designated ER5. RT-PCR analysis of ER5 expression revealed an early (15 min) and transient induction by ethylene in tomato fruit, leaves and roots.
Bouzayen, Mondher   +6 more
core   +2 more sources

Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

open access: yesAdvanced Science, EarlyView.
In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun   +7 more
wiley   +1 more source

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