Results 131 to 140 of about 718,053 (303)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Comprehensive evaluation and restoration management of ecological issues in abandoned mines in plateau-mountainous areas: A case study of Qujing City, Yunnan Province

Carsologica Sinica
Due to the early extensive development, the geomorphic landscape, land resources, and forest vegetation have been severely damaged. Coupled with the fragile ecological environment in the plateau-mountainous areas, the ecological problems caused by ...
Bo WANG, Li ZHAO, Yun GUO, Xiaomei CHEN, Zenghong SONG   +4 more
doaj   +1 more source

Biodiversity-ecosystem function relationships change in sign and magnitude across the Hill diversity spectrum. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Roswell M, Harrison T, Genung MA.
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Analysis of Causal Relationships Between Climate Perceptions and Ecological Production Among Tea Farmers in the Wuyi Mountains

Agriculture
Climate change adaptation in ecologically sensitive agriculture remains underexplored, especially regarding whether farmers’ climate perceptions translate into ecological production behaviors (EPBs). Using survey data from 730 tea farmers in China’s Wuyi
Han Zhang, Li Ma, Jiaming Liu, Jiaji Xing, Yilei Hou, Yali Wen   +5 more
doaj   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Impacts of an omnivorous ungulate on plant communities and soil organic carbon

Ecological Solutions and Evidence
Ungulates have been shown to affect multiple aspects of ecosystem composition and functions, including species diversity and carbon storage. Specifically, they can impact below‐ground carbon via both direct and indirect routes—the latter often occurring ...
Connor Lovell, Terence P. Dawson, Nathalie Pettorelli   +2 more
doaj   +1 more source

Response of grassland ecosystem function to plant functional traits under different vegetation restoration models in areas of karst desertification. [PDF]

Front Plant Sci, 2023
Song S, Xiong K, Chi Y.
europepmc   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Variation in near‐surface soil temperature drives plant assemblage differentiation across aspect

Ecology and Evolution
Quantifying assemblage variation across environmental gradients provides insight into the ecological and evolutionary mechanisms that differentiate assemblages locally within a larger climate regime.
Elizabeth G. Simpson, Ian Fraser, Hillary Woolf, William D. Pearse   +3 more
doaj   +1 more source