Results 191 to 200 of about 718,053 (303)

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Species abundances surpass richness effects in the biodiversity-ecosystem function relationship across marine fishes. [PDF]

Nat Commun
Yan HF, Morais RA, Bellwood DR.
europepmc   +1 more source

Effects of ocean acidification on marine biodiversity and ecosystem function [PDF]

, 2011
Barry, JP, Hall-Spencer, JM, Widdicombe, S   +2 more
core   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

Editorial: Revisiting the Biome Concept With A Functional Lens

Frontiers in Ecology and Evolution, 2019
Daniel M. Griffith, Christopher J. Still, Colin P. Osborne   +2 more
doaj   +1 more source

Cascading Effects of Plant Hormone-induced Trait Shifts in Alnus rubra on Aquatic and Terrestrial Ecosystem Function. [PDF]

J Chem Ecol
Broe TY, Fabiani A, Kuijpers MCM, Jackrel SL.   +3 more
europepmc   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Nutrient connectivity via seabirds enhances dynamic measures of coral reef ecosystem function. [PDF]

PLoS Biol
Benkwitt CE, Zora A, Ebrahim A, Govinden R, Lange ID, Evans S, Schulze M, Cotton E, Bennett L, Graham NAJ.   +9 more
europepmc   +1 more source

Publisher Correction: Consistent effects of pesticides on community structure and ecosystem function in freshwater systems. [PDF]

Nat Commun, 2021
Rumschlag SL, Mahon MB, Hoverman JT, Raffel TR, Carrick HJ, Hudson PJ, Rohr JR.   +6 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source