Results 141 to 150 of about 76,225 (314)

Invasive Species Population Status Modeling Using Stage Based Matrix: Mount Elgon Ecosystem

, 2019
The matrix models have been applied to evaluate the impacts and management of tree species. Modeling of invasive species using stage based matrix methods has not been exploited to understand the population structure of the invasive species.
Nyakinda, J. O., Okuto, E., Mullah, J. A., Ojung’a, S. O.   +3 more
core  

Revealing Invisible Water: Moisture Recycling as an Ecosystem Service

, 2015
These data are output from the STEAM+WAM modeling framework described in Keys et al. “Revealing Invisible Water: Moisture Recycling as an Ecosystem Service.” These data can be used to reconstruct the results of the paper (under the “Methods” section ...
Keys, P.W. (Patrick)
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

A bottom-up evolution of terrestrial ecosystem modeling theory, and ideas toward global vegetation modeling

, 1992
A primary purpose of this review is to convey lessons learned in the development of a forest ecosystem modeling approach, from it origins in 1973 as a single-tree water balance model to the current regional applications.
Running, Steven W.
core  

Using ecosystem modeling for fisheries management and marine ecosystem conservation: Where are we?

, 2005
No abstracts are to be cited without prior reference to the author.The writing is on the wall: we are moving toward ecosystem-based management of fisheries, and it is clear that ecosystem modeling is an important tool for evaluating scenarios and trade ...
Villy Christensen (138205), Carl J. Walters (8201883)   +1 more
core   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Aquaculture systems modeling: an introduction with emphasis on warmwater aquaculture [PDF]

An introduction to modeling is presented. The basic concepts of systems and models and various types of models and their use in research and in management are described.
Cuenco, M.L.
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