Results 161 to 170 of about 76,225 (314)

Cost–benefit analysis of ecosystem modeling to support fisheries management

Mathematical and statistical models underlie many of the world's most important fisheries management decisions. Since the 19th century, difficulty calibrating and fitting such models has been used to justify the selection of simple, stationary, single ...
Holden, Matthew H, Wickens, Montana, Heneghan, Ryan F., Saunders, Kate, Helmstedt, Kate J, Lovett, Robyn A., Timms, Liam, Adams, Matthew P, Plagányi, Eva E., Helmstedt, Kate J., Richardson, Anthony J, Fulton, Elizabeth A, Rogers, Jacob G. D., Botelho, Larissa Lubiana, Plaganyi, Eva E, Richardson, Anthony J., Heneghan, Ryan F, Holden, Matthew H., Dichmont, Catherine M., Dichmont, Catherine M, Janes, Rachel, Erm, Philip, Mendiolar, Manuela, Fulton, Elizabeth A., Campbell, Alexander B., Campbell, Alexander B, Lovett, Robyn A, Adams, Matthew P., et al.   +28 more
core   +1 more source

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

Advanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen, Wenliang Zhou, Lan Qiu, Han Lai, Mingpan Huang, Qian Li, Wen Yu, Pei‐Yuan Qian, Fuwen Wei   +8 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Payments for Ecosystem Services: Mechanisms to Achieve Desired Landscape Patterns

This paper evaluates the effectiveness of five payment for ecosystem service (PES) schemes at meeting conservation objectives when the spatial configuration is important in meeting desired landscape patterns.
Parkhurst, Gregory M
core  

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Accounting for changes in biodiversity and ecosystem services from a business perspective [PDF]

Biodiversity refers to the dynamics of interactions between organisms in changing environments. Within the context of accelerating biodiversity loss worldwide, firms are under increasing pressures from stakeholders to develop appropriate tools to account
Charlotte Pavageau, Michel Trommetter, Joël Houdet, Jacques Weber   +3 more
core  

The Future of Artificial Intelligence in Ecosystem Modeling. [PDF]

Bioscience
Spillias S, Trebilco R, Adams MP, Boschetti F, Constable A, Dunstan P, Ferrier S, Porobic J, Grimberg E, Grigg N, Harfoot M, Hirsch P, Hobday AJ, Holden M, Hutton T, Kaur S, Melbourne-Thomas J, Paris C, Parker D, Plagányi É, Rogers JGD, Stitzlein C, Weiley V, Wild-Allen K, Woolley SNC, Fulton EA.   +25 more
europepmc   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Combining Observations and Models: A Review of the CARDAMOM Framework for Data-Constrained Terrestrial Ecosystem Modeling. [PDF]

Glob Chang Biol
Worden MA, Bilir TE, Bloom AA, Fang J, Klinek LP, Konings AG, Levine PA, Milodowski DT, Quetin GR, Smallman TL, Bar-On YM, Braghiere RK, David CH, Fischer NA, Gentine P, Green TJ, Jones A, Liu J, Longo M, Ma S, Magney TS, Massoud EC, Myrgiotis V, Norton AJ, Parazoo N, Tajfar E, Trugman AT, Williams M, Worden S, Zhao W, Zhu S.   +30 more
europepmc   +1 more source