Results 101 to 110 of about 221,766 (261)
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
Ecosphere, 2016 Global change drivers influence ecological processes at multiple scales and manifest across most of Earth as changes in biodiversity, biogeochemical cycles, infectious disease incidence, and ecohydrology.
Andrea S. Thorpe +9 more
doaj +1 more source
Tropical forest degradation in the context of climate change: increasing role and research challenges. [K-2215-01] [PDF]
, 2015 While developed countries in temperate regions faced their forest transition about 100 years ago or more, “tropical forest rich” nations still largely depend on forest resources or land clearing for their development.
Chave, Jérôme +2 more
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MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts
Advanced Science, EarlyView.We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang +5 more
wiley +1 more source
BIOPERIANT12: a mesoscale-resolving coupled physics–biogeochemical model for the Southern Ocean [PDF]
Geoscientific Model DevelopmentWe present BIOPERIANT12, a regional 1/12° ocean–ice–biogeochemical model configuration of the Southern Ocean (SO) based on the Nucleus for European Modelling of the Ocean platform. It is designed to investigate mean state, seasonal cycle, and upper ocean
N. Chang +10 more
doaj +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
PICES Press, Vol. 15, No. 2, July 2007 [PDF]
, 2007 Contents [Individual sections are downloadable from the official URL link listed below]: PICES Science in 2007 (pdf, 0.1 Mb) 2007 Wooster Award (pdf, 0.1 Mb) FUTURE - A milestone reached but our task is not done (pdf, < 0.1 Mb) International ...
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Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Advanced Science, EarlyView.The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang +7 more
wiley +1 more source
Effect of mulched drip irrigation on crop biomass and carbon fluxes in maize field
Agricultural Water ManagementThe agroecosystem, a critical component of the terrestrial carbon cycle, plays an indispensable role in maintaining the balance of carbon pools and ensuring global food security.
Hui Guo, Xuhui Wang, Yahui Wang, Sien Li
doaj +1 more source