Results 71 to 80 of about 9,800 (223)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Olfactory Neuroblastoma Causing Ectopic ACTH Syndrome

Endocrine Journal, 2005
A 39-year-old woman who presented with typical Cushingoid appearance (moon facies, central obesity, purpura) was admitted to our hospital because of pulmonary infection. She was found to have hypertension, severe hypokalemia, and metabolic alkalosis. Endocrine data revealed elevated plasma levels of ACTH and cortisol with lack of circadian rhythm, non ...
Kazuo, Kanno, Yuki, Morokuma, Toru, Tateno, Yuki, Hirono, Kazuhiro, Taki, R Yoshiyuki, Osamura, Yukio, Hirata   +6 more
openaire   +3 more sources

Mid-gut ACTH-secreting neuroendocrine tumor unmasked with (18)F-dihydroxyphenylalanine-positron emission tomography. [PDF]

, 2015
Ectopic ACTH Cushing's syndrome (EAS) is often caused by neuroendocrine tumors (NETs) of lungs, pancreas, thymus, and other less frequent locations. Localizing the source of ACTH can be challenging.
Boubaker, A., Ducry, J., Gomez, F., Matter, M., Monti, M., Pitteloud, N., Portmann, L., Prior, J.O., Pu, Y.   +8 more
core   +1 more source

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, Volume 103, Issue 12, Page 781-889, December 2025.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source

Ectopic ACTH Production Leading to Diagnosis of Underlying Medullary Thyroid Carcinoma

Journal of Investigative Medicine High Impact Case Reports, 2016
Medullary thyroid carcinoma (MTC) has been described as a source of ectopic ACTH secretion in patients with Cushing’s syndrome. This is an infrequent association, occurring in less than 1% of MTC cases. Among these, it is even more unusual for an initial
Leslee N. Matheny MD, Jessica R. Wilson MD, Howard B. A. Baum MD   +2 more
doaj   +1 more source

HYPERPIGMENTATION AND ACTH – AN OVERVIEW OF LITERATURE [PDF]

Romanian Medical Journal, 2019
Introduction. ACTH (adrenocorticotropic hormone) is a key regulator of adrenal production involving cortisol as an essential hormone for life. The melanin is a pigment which is produced by melanocytes at the level of melanosomes (the melanogenesis ...
Florica Sandru, Mihai Cristian Dumitrascu, Simona Elena Albu, Mara Carsote, Ana Valea   +4 more
doaj   +1 more source

Ectopic ACTH Syndrome in Children and Adolescents [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2011
Ectopic ACTH syndrome (EAS) in youngsters has seldom been reported and is poorly known.We conducted a multicenter retrospective study involving 18 French tertiary hospitals. Cases of EAS presenting Cushing's syndrome before the age of 20 during the period from 1985 to 2008 were analyzed.Ten patients aged 14 to 20 yr were identified and compared to 20 ...
More, Julie, Young, Jacques, Reznik, Yves, Raverot, Gérald, Borson-Chazot, Françoise, Rohmer, Vincent, Baudin, Eric, Coutant, Régis, Tabarin, Antoine, Renseigné, Non   +9 more
openaire   +3 more sources

Uneventful octreotide LAR therapy throughout three pregnancies, with favorable delivery and anthropometric measures for each newborn: a case report [PDF]

, 2011
Introduction The safety of octreotide use, in its short-acting preparation, in pregnancy is still unclear. This report provides the first documentation of uneventful octreotide LAR use during three pregnancies in a woman with bronchial carcinoid ...
Deeb Daoud Naccache, Adnan Zaina, Zila Shen-Or, Michal Armoni, George Kontogeorgos, Ali Yahia   +5 more
core   +2 more sources

Silent Threat: A Complex Presentation of Testicular Adrenal Rest Tumors in a Male With Congenital Adrenal Hyperplasia

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Congenital adrenal hyperplasia (CAH) with testicular adrenal rest tumor (TART) is a sequela of 21‐hydroxylase deficiency in the background of adrenal hyperplasia in most cases. We report a case of a 10‐year‐old boy who presented with a 7‐day history of headache, vomiting, and abdominal pain, and had a blood pressure of 200/140 mmHg with a ...
Shristi Gupta, Aron Neupane, Kshitiz Parajuli, Sagar Bhagat, Nischal Timsina, Raja Babu Gupta   +5 more
wiley   +1 more source

Síndrome de Cushing na gravidez: uma visão geral [PDF]

, 2007
Cushing's syndrome (CS) during pregnancy is a rare condition with fewer than 150 cases reported in the literature. Adrenal adenomas were found to be the commonest cause, followed by Cushing's disease.
Freitas, Maria da Conceição, Kater, Claudio Elias, Lima, Lúcia Helena C., Lyra, Ruy, Vilar, Lucio   +4 more
core   +3 more sources