Results 31 to 40 of about 786 (183)

Inactivating PTH/PTHrP signaling disorders (iPPSDs): evaluation of the new classification in a multicenter large series of 544 molecularly characterized patients

, 2021
International audienceObjective Pseudohypoparathyroidism and related disorders belong to a group of heterogeneous rare diseases that share an impaired signaling downstream of Gsα-protein-coupled receptors.
Francou, Bruno, Ertl, Diana Alexandra, Thiele, Suzanne, de Sanctis, Luisa, Linglart, Agnès, Elli, Francesca, Hanna, Patrick, Pereda, Arrate, Rothenbuhler, Anya, Perez de Nanclares, Guiomar, Mantovani, Giovanna   +10 more
core   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, EarlyView.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

Postoperative Exostosis: Ectopic Ossification After Pericardial Window Procedure

Annals of Thoracic Surgery Short Reports, 2023
A 58-year-old Hispanic man had persistent epigastric pain after pericardial window procedure for viral pericarditis several years earlier. After review of a computed tomography scan, a calcified epigastric subcutaneous mass was detected. The patient elected to undergo surgical excision of the mass, which revealed a heterotopic ossified lesion arising ...
Ahmed Mostafa, Mohamad Alhalabieh, Dimitrios Xourafas, Tiffany Schatz   +3 more
openaire   +2 more sources

Intramuscular myxoma with chondroid features: two cases expanding the morphological spectrum

Histopathology, EarlyView.
Background Intramuscular myxoma is a benign mesenchymal tumour typically composed of bland spindle to stellate cells in abundant myxoid stroma and usually characterized by GNAS mutations. Chondroid matrix has not been previously reported in intramuscular myxoma.
Bethany Batson, Azfar Neyaz, Lucas Da Gama Lobo, Rana Naous, Stella J Lee, Ivy John   +5 more
wiley   +1 more source

Ectopic Ossification in the Scar Tissue of Rats with Myocardial Infarction

Cell Transplantation, 2006
We describe the occurrence of bone-like formations in the left ventricular wall of infarcted rats treated or not with bone marrow cells injected systemically or locally into the myocardium. The incidence of ectopic calcification in hearts has been reported in rare cases in children with infarcts without previous coronary artery disease.
Karla Consort Ribeiro, Elisabete César Mattos, João Pedro Saar Werneck-de-Castro, Vanessa Pinho Ribeiro, Ricardo Henrique Costa-e-Sousa, Amarildo Miranda, Emerson Lopes Olivares, Marcos Farina, José Geraldo Mill, Regina Coeli dos Santos Goldenberg, Masako Oya Masuda, Antônio Carlos Campos de Carvalho   +11 more
openaire   +4 more sources

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, Volume 13, Issue 37, 3 July 2026.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Essential embryology for the Canadian pathologists’ assistant

Anatomical Sciences Education, Volume 19, Issue 7, Page 1134-1156, July 2026.
Abstract Pathologists' assistants (PAs) are pivotal in healthcare, conducting autopsies and examining tissues under a pathologist's guidance. Embryology knowledge is crucial for PAs to accurately assess anomalies and identify pathologies. Yet, it is often overlooked in academic PA training programs.
Samantha H. Nacci, William Tsui, Fang‐I Lu, Avrum I. Gotlieb, Danielle C. Bentley   +4 more
wiley   +1 more source

Strong relationship between dyslipidemia and the ectopic ossification of the spinal ligaments

Scientific Reports, 2022
Abstract Obesity and metabolic disturbances are prevalent in ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF); however, the involvement of dyslipidemia (DL) in OPLL/OLF remains uncertain. We investigated the association between dyslipidemia and OPLL/OLF using a dataset of 458 individuals
Endo, Tsutomu, Takahata, Masahiko, Fujita, Ryo, Koike, Yoshinao, Suzuki, Ryota, Hasegawa, Yuichi, Murakami, Toshifumi, Ishii, Misaki, Yamada, Katsuhisa, Sudo, Hideki, Iwasaki, Norimasa   +10 more
openaire   +4 more sources