Results 41 to 50 of about 81,488 (341)
The Philosophical Quarterly, 2018 Ridge defends a form of hybrid expressivism where normative judgements are constituted by two elements, normative perspectives and representational beliefs that invoke standards our normative perspectives determine. He thinks this view will enable him to ‘offload logical complexity’ onto the latter, representational components of our judgements ...
openaire +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Religions, 2023 This study analyses several of the key principles of Father Dumitru Stăniloae’s conception of Orthodox ecumenical theology. It considers the foundations, the possibilities, and the type of ecumenical manifestation, specifically regarding the ...
Nathanael Neacșu
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Coming to Terms with the Reformation
Open Theology, 2018 The quincentenary of the Reformation in 2017 challenged different actors or subjects (such as civil societies, states, and churches) to come to terms with ‟the” Reformation.
Dieter Theodor
doaj +1 more source
Commentary on the Lutheran Book of Worship: Lutheran Liturgy in Its Ecumenical Context [PDF]
, 1994 Reviewed Book: Pfatteicher, Philip H. Commentary on the Lutheran Book of Worship: Lutheran Liturgy in Its Ecumenical Context.
Nevile, Donald C.
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Initiation into Christ: Ecumenical Reflections and Common Teachings on Preparation for Baptism [PDF]
, 1994 Reviewed Book: Canadian Council of Churches. Initiation into Christ: Ecumenical Reflections and Common Teachings on Preparation for Baptism.
Nevile, Donald C.
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source