An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Coming to Terms with the Reformation
The quincentenary of the Reformation in 2017 challenged different actors or subjects (such as civil societies, states, and churches) to come to terms with ‟the” Reformation.
Dieter Theodor
doaj +1 more source
Comparison as Collaboration: Notes on the Contemporary Craft of Hagiology
A workshop on “comparative hagiology” over the course of three years at the American Academy of Religion has yielded not only a series of articles but an experimental methodology by which scholars hailing from different disciplines and ...
Aaron T. Hollander
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Inter-Religious Dialogue as a Christian Ecumenical Concern
Explores inter-religious dialogue in Christian ecumenical concerns. Discussion of mission and evangelism by the Commission on World Mission and Evangelism; Theological, developmental and peace-making work of the Church and Church bodies; Dialogue and ...
Eck, Diana, Diana L. Eck
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A meta-ethical approach to single-player gamespace: introducing constructive ecumenical expressivism as a means of explaining why moral consensus is not forthcoming [PDF]
The morality of virtual representations and the enactment of prohibited activities within single - player gamespace (e.g., murder, rape, paedophilia) continues to be debated and, to date, a consensus is not forthcoming.
Young, G
core +1 more source
A reading of the 9th Assembly: God, in Your Grace, transform the world [PDF]
Graham McGeoch considers the 9th Assembly of the World Council of Churches in the context of previous assemblies and of changing circumstances which have required the Council to focus its activities.
McGeoch, Graham
core +2 more sources
The Faces of the Central Eastern European Region in Hymnals of the Global Ecumenical Movement
Motivated by the 2023 Kraków assembly of the Lutheran World Federation (LWF), the article offers an insight into the formation of global hymnals from a Central Eastern European (CEE) perspective.
Pap Kinga Marjatta
doaj +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source

