Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure [PDF]
, 2008 Background Loss-of-function variants in the gene encoding filaggrin (FLG) are major determinants of eczema. We hypothesized that weakening of the physical barrier in FLG-deficient individuals may potentiate the effect of environmental exposures ...
Adnan Custovic +32 more
core +4 more sources
Acta Dermato-Venereologica, 2022 Data on chronic hand eczema and severity of hand eczema in the general population is scarce. In this cross-sectional study, a questionnaire was sent to 135,950 Lifelines Cohort Study participants, in order to investigate the prevalence and severity of ...
Angelique N. Voorberg +2 more
doaj +1 more source
A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema
Gut microbes, 2020 Evidence is accumulating that the establishment of the gut microbiome in early life influences the development of atopic eczema. In this longitudinal study, we used integrated multi-omics analyses to infer functional mechanisms by which the microbiome ...
L. Ta +27 more
semanticscholar +1 more source
Siblings, asthma, rhinoconjunctivitis and eczema: a worldwide perspective from the International Study of Asthma and Allergies in Childhood. [PDF]
, 2014 BACKGROUND: Associations of larger families with lower prevalences of hay fever, eczema and objective markers of allergic sensitization have been found fairly consistently in affluent countries, but little is known about these relationships in less ...
Aït-Khaled, N +7 more
core +2 more sources
Frequent use of paracetamol and risk of allergic disease among women in an Ethiopian population [PDF]
, 2011 Introduction The hypothesis that paracetamol might increase the risk of asthma and other allergic diseases have gained support from a range of independent studies.
A Amberbir +31 more
core +10 more sources
JAAD International, 2023 Background: Research has shown that eczema patients prefer some degree of shared control over treatment decisions, but little is known about factors perceived to be important to facilitate shared decision making (SDM).
Erin Foster, MD, PhD +3 more
doaj
Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: a potential role of recombination in emergence and pathogenicity [PDF]
, 2015 Human coxsackievirus A6 (CVA6) is an enterically transmitted enterovirus. Until recently, CVA6 infections were considered as being of minor clinical significance, and only rarely aetiologically linked with hand, foot and mouth disease (HFMD) associated ...
Gaunt, E +6 more
core +1 more source
Paediatrics & Child Health, 2000 Eczema is a term used to describe a variety of conditions which primarily include atopic dermatitis, seborrheic dermatitis, contact dermatitis, both irritant and allergic, scabies, tinea infections and immunodeficiencies. Some physicians use the term solely to describe atopic dermatitis.
openaire +2 more sources
BMC Medicine, 2023 Background Psoriasis and atopic eczema are common inflammatory skin diseases. Existing research has identified increased risks of common mental disorders (anxiety, depression) in people with eczema and psoriasis; however, explanations for the ...
Alasdair D. Henderson +9 more
doaj +1 more source
Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study. [PDF]
, 2018 Background2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental contaminant that can bioaccumulate in humans, cross the placenta, and cause immunological effects in children, including altering their risk of developing allergies. On July 10,
Brambilla, Paolo +4 more
core +2 more sources