Results 61 to 70 of about 157,660 (290)

Taste Profile and Relative Bioavailability of Tovorafenib Powder for Oral Suspension and Food Effect of the Tovorafenib Tablet in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A pediatric‐friendly powder for oral suspension (PfOS) of tovorafenib, a type II RAF inhibitor, was developed for patients with difficulty swallowing tablets. This open‐label, randomized, phase 1 study (QSC205140) evaluated the taste/palatability of PfOS formulations (n = 12), the relative bioavailability of the PfOS versus tablet formulation,
Yang Zhang, Mike Preigh, Jing Wang, Eleni Venetsanakos, Yujin Wang, Elly Barry, Don Corson   +6 more
wiley   +1 more source

Clinical Features and Awareness of Hand Eczema in Korea [PDF]

, 2016
Background: Hand eczema is one of the most common skin disorders and negatively affects quality of life. However, a large-scale multicenter study investigating the clinical features of patients with hand eczema has not yet been conducted in Korea ...
���������
core   +2 more sources

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Application of Bryophytes to Foods, Food Additives and Phytomedicines

Food Chemistry International, EarlyView.
Little attention has been paid to the bryophytes for use in the human diet, despite the presence of 23,000 species worldwide. (Marchantia polymorpha). ABSTRACT Little attention has been paid to the bryophytes for application on the human diet, despite the presence of 23,000 species worldwide.
Yoshinori Asakawa, Jianbo Xiao
wiley   +1 more source

How has the COVID‐19 pandemic affected eczema self‐management and help seeking? A qualitative interview study with young people and parents/carers of children with eczema

Skin Health and Disease, 2021
Background Eczema can have a considerable impact on quality of life. Treatments can improve this, but management is complex. Barriers to eczema self‐management may be impacted upon by environmental context, such as the COVID‐19 pandemic.
M. Steele, L. Howells, M. Santer, K. Sivyer, S. Lawton, A. Roberts, E. Teasdale, I. Muller, K. Greenwell   +8 more
doaj   +1 more source

Essential fatty acid deficiency, olive oil‐based intravenous lipid emulsion, and genetic polymorphisms: A pediatric randomized controlled trial

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives There is a concern that decreasing soybean oil (SO) content in intravenous lipid emulsions (ILEs) may increase the risk for essential fatty acid deficiency (EFAD). This study evaluates the risk of EFAD in pediatric patients who were expected to require parenteral nutrition for at least 7 days with an 80% olive oil/20% SO ILE (OO/SO ...
Cynthia Blanco, Weili Chang, Abhay J. Bhatt, Erick Gerday, Ajay J. Talati, Narendra Dereddy, Rachana Singh, Erika Ryan, Thibault Senterre   +8 more
wiley   +1 more source

Reliable Detection of Eczema Areas for Fully Automated Assessment of Eczema Severity from Digital Camera Images

JID Innovations, 2023
Assessing the severity of eczema in clinical research requires face-to-face skin examination by trained staff. Such approaches are resource-intensive for participants and staff, challenging during pandemics, and prone to inter- and intra-observer ...
Rahman Attar, Guillem Hurault, Zihao Wang, Ricardo Mokhtari, Kevin Pan, Bayanne Olabi, Eleanor Earp, Lloyd Steele, Hywel C. Williams, Reiko J. Tanaka   +9 more
doaj  

Debates in allergy medicine: Specific immunotherapy in children with atopic dermatitis, the "con" view. [PDF]

, 2016
Atopic dermatitis (AD) is a common chronic skin condition in children that has a proven association with other atopic conditions and allergies. These associations, like the general pathophysiology of AD, are complex and not fully understood.
Eichenfield, Lawrence F, Ginsberg, David N   +1 more
core   +3 more sources

Genital Crohn's disease in pediatrics and genetic associations

JPGN Reports, EarlyView.
Abstract Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co‐occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote ...
Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak   +5 more
wiley   +1 more source

Patients’ and Caregivers’ Experiences Navigating the Burden of Atopic Dermatitis in Argentina

Medicina
Background and Objectives: Little is known about patients’ and caregivers’ experiences with atopic dermatitis (AD) in Argentina, so a survey was administered to learn more.
Korey Capozza, Michelle Tu, Alan Schwartz, Jodi L. Johnson, Mónica Ladner   +4 more
doaj   +1 more source