Results 91 to 100 of about 2,131 (192)

Improvement in Atopic Dermatitis and Recurrent Infection With Dupilumab in Children With Distinct Genetic Types of Hyper‐IgE Syndrome: A Case Series and Literature Review

Pediatric Dermatology, Volume 42, Issue 2, Page 376-382, March/April 2025.
ABSTRACT Hyperimmunoglobulin E syndrome (HIES) is a group of rare genetic disorders characterized by severe atopic dermatitis and recurrent skin and pulmonary infections. The efficacy of dupilumab in pediatric patients with HIES‐associated severe atopic dermatitis is relatively understudied.
Jenna K. Dick, Christina Boull, Tamara C. Pozos, Sheilagh M. Maguiness   +3 more
wiley   +1 more source

Infections in Patients with Atopic Dermatitis and the Infuence of Treatment [PDF]

Atopic dermatitis (AD) is a T helper 2-mediated chronic infammatory skin disease that afects children and adults. Patients with AD are prone to recurrent infections of the skin and other organs, which can severely worsen the disease course. This review
Maddalena Napolitano, · Caterina Foti, · Elena Nicoli, · Giampiero Girolomoni, · Maria Concetta Fargnoli, · Maria Esposito, · Paolo Matruglio, · Paolo Romita   +7 more
core   +5 more sources

An 8-Month-Old Girl With Vesicular Rash

Global Pediatric Health, 2019
This is a case report of an 8-month-old girl who presented to the pediatric emergency department with vesicular rash and fever. She was diagnosed with eczema herpeticum (EH). EH is an acute, rapidly progressive rare dermatologic disease, and if it is not
Ali Ozcan MD, Kristin Kahale MD, Dan Nguyen MD   +2 more
doaj   +1 more source

IL-4 impairs wound healing potential in the skin by repressing fibronectin expression [PDF]

, 2017
BACKGROUND: Atopic dermatitis (AD) is characterized by intense pruritis and is a common childhood inflammatory disease. Many factors are known to affect AD development, including the pleiotropic cytokine IL-4.
Bozdogan, Gunseli, Goenka, Shreevrat, Kaplan, Mark H., Krishnamurthy, Purna, Nalepa, Grzegorz, Potchanant, Elizabeth A Sierra, Sehra, Sarita, Serezani, Ana PM, Spandau, Dan F., Turner, Matthew J., Walsh, Daniel   +10 more
core   +2 more sources

Low Infection Rates With Long‐Term Dupilumab Treatment in Patients Aged 6 Months to 5 Years: An Open‐Label Extension Study

Pediatric Dermatology, Volume 42, Issue 2, Page 251-258, March/April 2025.
ABSTRACT Objective To evaluate long‐term infection rates in children aged 6 months to 5 years with moderate‐to‐severe atopic dermatitis (AD) treated with dupilumab. Methods This was a post hoc analysis of an ongoing open‐label extension (OLE) study of dupilumab.
Amy S. Paller, Michele Ramien, Michael J. Cork, Eric L. Simpson, Lara Wine Lee, Lawrence F. Eichenfield, Faisal A. Khokhar, Anna Coleman, Guy Gherardi, Zhen Chen, Annie Zhang, Sonya L. Cyr   +11 more
wiley   +1 more source

Unusual localization of eczema herpeticum to tinea corporis and cruris

Clinical Dermatology Review
Eczema herpeticum (EH), known as Kaposi varicelliform eruption presents with multiple vesiculopustular lesions localized to areas of preexisting eczematous or erosive dermatoses.
Soumya Narula, K Shreya, Mukesh K Sahni, Dinesh P Asati   +3 more
doaj   +1 more source

Mannan-Binding Lectin Levels and Activity Are Not Altered in Atopic Dermatitis Patients with a History of Eczema Herpeticum

Dermatology Research and Practice, 2011
Background. Eczema herpeticum (EH) is a potentially serious, systemic complication in subjects with atopic dermatitis (AD) caused by herpes simplex virus (HSV).
Kemp W. Bundy, Laura Y. McGirt, Lora G. Bankova, Andreas Wollenberg, Lisa A. Beck, Anna De Benedetto   +5 more
doaj   +1 more source

Recurring eczema herpeticum complicated by herpetic meningitis and staphylococcal bacteremia

JEM Reports
Background: Eczema Herpeticum (EH) is a dermatological emergency that may progress to viral meningitis in patients not treated urgently. We present a case of recurrent EH in a young, immunocompetent patient complicated by progressing herpetic meningitis ...
Morgan C. Lain, John R. Bales, Mahmoud D. Al-Fadhl, Anthony V. Thomas, Hamid D. Al-Fadhl, Uzma Rizvi, Joseph B. Miller, Bruce D. Harley, Mark M. Walsh   +8 more
doaj   +1 more source

Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion. [PDF]

, 2016
The host responds to virus infection by activating type I interferon (IFN) signaling leading to expression of IFN-stimulated genes (ISGs). Dysregulation of the IFN response results in inflammatory diseases and chronic infections.
Bozzacco, Leonia, Breton, Gaëlle, Hoffmann, Hans-Heinrich, Li, Melody MH, Loschko, Jakob, MacDonald, Margaret R, Monette, Sébastien, Rice, Charles M, Xiao, Jing W   +8 more
core  

Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation [PDF]

, 2017
Langerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting the microenvironmental context in which they encounter foreign substances, but the regulatory basis for this has not been established.
A Conesa, A Del Prete, A Masumi, A Schlitzer, A Shahdadfar, A Staudacher, AM McCollum, AM van der Aar, AN Ahyi, C Munz, C Rommel, CJ Spooner, D Ruths, DG Winkler, DS Borkar, E Banham-Hall, E Glasmacher, E Hirsch, FK Puttur, G Csardi, G Karlebach, G Ratzinger, H Singh, I Amit, I Arisi, J Banchereau, J Berghout, J Bourdon, J Chen, J Liu, J Seneschal, J Seneschal, J Xue, JA Papin, JE Bailey, JE Scott, JW Williams, K Ochiai, KK Farh, L Gabriele, L Glass, L Newell, L O’Hara, L Shi, LJ Steggles, M Akbari, M Behar, M Camps, M Contoli, M Gupta, M Kim, M Peleg, ME Polak, ME Polak, MJ Aryee, NA Mabbott, P Fauque, P Laslo, P Li, P Petermann, PM Loriaux, PM Loriaux, R Tussiwand, R Tussiwand, RA Mathias, S Ebner, S Li, S Marecki, S Roy, SL Werner, SL Werner, SW Kim, T Friedlander, TC Freeman, V Soumelis, VF Shih, VF Shih, WM Peng, WR Swindell, Z Tian   +79 more
core   +2 more sources