Results 121 to 130 of about 1,370 (154)

Cytoplasmic mRNA decay and quality control machineries in eukaryotes. [PDF]

Nat Rev Genet
Dowdle ME, Lykke-Andersen J.
europepmc   +1 more source

DDX6 modulates P-body and stress granule assembly, composition, and docking. [PDF]

J Cell Biol
Ripin N, Macedo de Vasconcelos L, Ugay DA, Parker R.   +3 more
europepmc   +1 more source

Tag with Caution — How protein tagging influences the formation of condensates

Dörner K, Gut M, Overwijn D, Cao F, Siketanc M, Heinrich S, Beuret N, Sharpe T, Lindorff-Larsen K, Maria H.   +9 more
europepmc   +1 more source

The phase separation landscape of genome-wide genetic perturbations

Heidenreich M, Mathur S, Shu T, Xie Y, Sriker D, Dubreuil B, Holt L, Levy ED.   +7 more
europepmc   +1 more source

Fertilization triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development

Araoyinbo A, Salat-Canela C, Vještica A.   +2 more
europepmc   +1 more source

Similar Modes of Interaction Enable Trailer Hitch and EDC3 To Associate with DCP1 and Me31B in Distinct Protein Complexes [PDF]

Molecular and Cellular Biology, 2008
Trailer Hitch (Tral or LSm15) and enhancer of decapping-3 (EDC3 or LSm16) are conserved eukaryotic members of the (L)Sm (Sm and Like-Sm) protein family. They have a similar domain organization, characterized by an N-terminal LSm domain and a central FDF motif; however, in Tral, the FDF motif is flanked by regions rich in charged residues, whereas in ...
Oliver Weichenrieder, Murray Coles, Elisa Izaurralde   +2 more
exaly   +5 more sources

A Divergent Sm Fold in EDC3 Proteins Mediates DCP1 Binding and P-Body Targeting [PDF]

Molecular and Cellular Biology, 2007
Members of the (L)Sm (Sm and Sm-like) protein family are found across all kingdoms of life and play crucial roles in RNA metabolism. The P-body component EDC3 (enhancer of decapping 3) is a divergent member of this family that functions in mRNA decapping. EDC3 is composed of a N-terminal LSm domain, a central FDF domain, and a C-terminal YjeF-N domain.
Oliver Weichenrieder, Murray Coles, Marcus Hartmann   +2 more
exaly   +6 more sources

Structural analysis of the yeast Dhh1-Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions. [PDF]

Nucleic Acids Research, 2013
Translational repression and deadenylation of eukaryotic mRNAs result either in the sequestration of the transcripts in a nontranslatable pool or in their degradation. Removal of the 5' cap structure is a crucial step that commits deadenylated mRNAs to 5'-to-3' degradation.
Elena Conti, Humayun Sharif, Henning Urlaub   +2 more
exaly   +8 more sources

Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment. [PDF]

Human Molecular Genetics, 2015
There are two known mRNA degradation pathways, 3' to 5' and 5' to 3'. We identified likely pathogenic variants in two genes involved in these two pathways in individuals with intellectual disability. In a large family with multiple branches, we identified biallelic variants in DCPS in three affected individuals; a splice site variant (c.636+1G>A) that ...
Heinrich Sticht, Melissa T Carter, Rebecca Buchert   +2 more
exaly   +5 more sources

Structural Basis for the Mutually Exclusive Anchoring of P Body Components EDC3 and Tral to the DEAD Box Protein DDX6/Me31B [PDF]

Molecular Cell, 2009
The DEAD box helicase DDX6/Me31B functions in translational repression and mRNA decapping. How particular RNA helicases are recruited specifically to distinct functional complexes is poorly understood. We present the crystal structure of the DDX6 C-terminal RecA-like domain bound to a highly conserved FDF sequence motif in the decapping activator EDC3.
Oliver Weichenrieder, Elisa Izaurralde, Ana Eulalio   +2 more
exaly   +5 more sources