Results 131 to 140 of about 1,370 (154)
EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
EMBO Reports, 2021 Regulation of mRNA stability and translation plays a critical role in determining protein abundance within cells. Processing bodies (P-bodies) are critical regulators of these processes. Here, we report that the Pim1 and 3 protein kinases bind to the P-body protein enhancer of mRNA decapping 3 (EDC3) and phosphorylate EDC3 on serine (S)161, thereby ...
Anne E Cress +2 more
exaly +3 more sources
Crystal Structure of Human Edc3 and Its Functional Implications [PDF]
Molecular and Cellular Biology, 2008 Edc3 is an enhancer of decapping and serves as a scaffold that aggregates mRNA ribonucleoproteins together for P-body formation. Edc3 forms a network of interactions with the components of the mRNA decapping machinery and has a modular domain architecture consisting of an N-terminal Lsm domain, a central FDF domain, and a C-terminal YjeF-N domain.
Martin A. Walsh, Haiwei Song, Roy Parker
exaly +3 more sources
Edc3 Function in Yeast and Mammals Is Modulated by Interaction with NAD-Related Compounds [PDF]
G3: Genes, Genomes, Genetics, 2014 Abstract The control of mRNA translation and degradation is mediated in part by a set of proteins that can inhibit translation and promote decapping, as well as function in the assembly of cytoplasmic mRNP granules referred to as processing bodies (P-bodies).
Wladek Minor, Je-Hyun Yoon, Roy Parker
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Journal of Microbiology, 2015
Candida albicans is an opportunistic fungal pathogen whose responses to environmental changes are associated with the virulence attributes. Edc3 is known to be an enhancer of the mRNA decapping reactions and a scaffold protein of cytoplasmic processing bodies (P-bodies). Recent studies of C.
Jinmi Kim
exaly +3 more sources
Candida albicans is an opportunistic fungal pathogen whose responses to environmental changes are associated with the virulence attributes. Edc3 is known to be an enhancer of the mRNA decapping reactions and a scaffold protein of cytoplasmic processing bodies (P-bodies). Recent studies of C.
Jinmi Kim
exaly +3 more sources
Fungal Genetics and Biology, 2016
Candida albicans, an opportunistic fungal pathogen, displays apoptotic cell death in response to various stresses and a wide range of antifungal treatments. CaMca1, which is the only metacaspase in C. albicans, has been described as a key player in apoptotic cell death.
Jeong-Hoon, Jeong +2 more
openaire +2 more sources
Candida albicans, an opportunistic fungal pathogen, displays apoptotic cell death in response to various stresses and a wide range of antifungal treatments. CaMca1, which is the only metacaspase in C. albicans, has been described as a key player in apoptotic cell death.
Jeong-Hoon, Jeong +2 more
openaire +2 more sources
EDC3 protein of P-body suppresses PRRSV proliferation and functions by upregulating MyD88
Veterinary MicrobiologyPorcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses to the swine industry worldwide. Despite numerous studies on this virus, the molecular mechanisms underlying PRRSV infection remain unclear. Enhancer of mRNA decapping 3 (EDC3) is a crucial scaffold protein for P-body assembly that stimulates mRNA decapping ...
Yiran, Wang +6 more
exaly +3 more sources
Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator
Nature Structural and Molecular Biology, 2016Elimination of the 5' cap of eukaryotic mRNAs, known as decapping, is considered to be a crucial, irreversible and highly regulated step required for the rapid degradation of mRNA by Xrn1, the major cytoplasmic 5'-3' exonuclease. Decapping is accomplished by the recruitment of a protein complex formed by the Dcp2 catalytic subunit and its Dcp1 cofactor.
Bertrand Séraphin +2 more
exaly +5 more sources
Cancer Research, 2021
Abstract Processing bodies (P-bodies) are cytoplasmic mRNA granules that form a hub to regulate mRNA translation via controlling decapping, degradation, and storage. P-bodies markedly increase as part of a stress response for example during nutrient deprivation and hypoxia. Thus, P-bodies could regulate cell fate by tuning protein levels
Jeremiah Bearss +5 more
openaire +1 more source
Abstract Processing bodies (P-bodies) are cytoplasmic mRNA granules that form a hub to regulate mRNA translation via controlling decapping, degradation, and storage. P-bodies markedly increase as part of a stress response for example during nutrient deprivation and hypoxia. Thus, P-bodies could regulate cell fate by tuning protein levels
Jeremiah Bearss +5 more
openaire +1 more source
The FEBS Journal, 2014
The Edc3 protein is an enhancer of mRNA decapping, and acts as a scaffold protein for the mRNA granules that are known as processing bodies in yeast. In the pathogenic yeast Candida albicans, various stresses, such as glucose depletion, oxidative stress, and filamentation defects, induce the accumulation of processing bodies.
Jong-Hwan, Jung, Jinmi, Kim
openaire +2 more sources
The Edc3 protein is an enhancer of mRNA decapping, and acts as a scaffold protein for the mRNA granules that are known as processing bodies in yeast. In the pathogenic yeast Candida albicans, various stresses, such as glucose depletion, oxidative stress, and filamentation defects, induce the accumulation of processing bodies.
Jong-Hwan, Jung, Jinmi, Kim
openaire +2 more sources
2007
mRNA degradation is a fundamental process that controls both the level and the fidelity of gene expression. Using a combination of bioinformatic, genomic, genetic, and molecular biology approaches, we have shown that Edc3p, a yeast mRNA decay factor, controls the stability of the intron-containing YRA1 pre-mRNA. We found that Edc3p-mediated degradation
openaire +2 more sources
mRNA degradation is a fundamental process that controls both the level and the fidelity of gene expression. Using a combination of bioinformatic, genomic, genetic, and molecular biology approaches, we have shown that Edc3p, a yeast mRNA decay factor, controls the stability of the intron-containing YRA1 pre-mRNA. We found that Edc3p-mediated degradation
openaire +2 more sources