Results 71 to 80 of about 1,370 (154)

The Role of Edc3 in Drosophila Melanogaster Neuronal Development

Enhancer of mRNA-decay 3 (Edc3) is a component of multiple decapping complexes that regulates the transcriptome by targeting a subset of transcripts for decapping for 5’-to-3’ messenger RNA (mRNA) decay. A missense mutation in the conserved Lsm domain of
Zius, Keelan
core   +1 more source

(Table S1) Tie points between the EDC3 ice age scale and the ice age scale used in this study

, 2013
(Table S1) Tie points between the EDC3 ice age scale and the ice age scale used in this ...
Parrenin, Frédéric, Carlo Barbante (7886291), Valerie Masson-Delmotte (492341), Masson-Delmotte, Valerie, Jean Jouzel (6970079), Frédéric Parrenin (6966464), Dominique Raynaud (6972491), Jouzel, Jean, Didier Paillard (6967616), Jakob Schwander (6975836), Schwander, Jakob, Anna Wegner (6961826), Landais, Amaëlle, Wegner, Anna, Peter Köhler (6964394), Amaelle Landais (7975406), Barbante, Carlo, Köhler, Peter, Paillard, Didier, Raynaud, Dominique   +19 more
core   +1 more source

Structural basis for the multiple roles Edc3 plays in mRNA degradation

, 2013
The Dcp1:Dcp2 decapping complex catalyzes the removal of the protecting 5’ cap structure from mRNA. Adaptor proteins, including Edc3 (enhancer of decapping 3), modulate this decapping process through multiple mechanisms.
Hoffmann, N., Fromm, S., Sprangers, R., Meylan, C., Fuchs, A., Truffault, V.   +5 more
core  

Dcp2 C-terminal -binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes

, 2022
A single Dcp1-Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5' to 3' decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive.
Wu, Chan, Jacobson, Allan, He, Feng
core   +1 more source

Additional file 2 of Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability

, 2018
Figure S1 Validation of SKNBE transcriptome data via qPCR. Comparison between fold changes obtained with RNA sequencing and with real time qPCR of selected genes. Direction of fold change was confirmed for 9 out of 10 assayed genes. (PDF 111 kb)
Scheller, Ute, Pfisterer, Kathrin, Uebe, Steffen, Ekici, Arif, Reis, AndrĂŠ, Jamra, Rami, Ferrazzi, Fulvia   +6 more
openaire   +1 more source

Additional file 8 of Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability

, 2018
Figure S3 Principal component analysis plot for transcriptome profiles of SKNBE samples. Plot of the first two components obtained by principal component analysis of the five knockdown and three control samples. (PDF 309 kb)
Scheller, Ute, Pfisterer, Kathrin, Uebe, Steffen, Ekici, Arif, Reis, AndrĂŠ, Jamra, Rami, Ferrazzi, Fulvia   +6 more
openaire   +1 more source

Cellular distributions of Dcp2, Dhh1, Edc3, and Xrn1 overlap under heat stress conditions.

, 2015
Localization patterns of Xrn1-GFP in control (A) and heat-stressed cells (B) were superimposed with the distributions of Dcp2-RFP (strain CRY1396), Dhh1-RFP (CRY2244) and Edc3-mCherry (CRY2245).
Tomas Grousl (382128), Miroslava Opekarová (172850), Jiri Hasek (382134), Jan Malinsky (172856), Vendula Stradalova (172840)   +4 more
core   +1 more source

(Table 2) Tuning points used to transfer the new EDC3/EDML1 chronology of core MD02-2588 to nearby core MD96-2080

, 2013
(Table 2) Tuning points used to transfer the new EDC3/EDML1 chronology of core MD02-2588 to nearby core MD96 ...
Purcell, Conor, Patrizia Ziveri (6959471), Zahn, Rainer, Rainer Zahn (6965303), Gregor Knorr (6971348), Gianluca Marino (6976136), Elderfield, Henry, Marino, Gianluca, Ziveri, Patrizia, Martin Ziegler (6967451), Conor Purcell (6670751), Ian R Hall (6965300), Ziegler, Martin, Knorr, Gregor, Hall, Ian R, Henry Elderfield (6959723)   +15 more
core   +1 more source

Additional file 6 of Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability

, 2018
Figure S2 Live Cell Images of differentiated and not differentiated SKNBE cells. a) Images after 72 h of culture. In cells treated with differentiation medium (from left to right: not transfected; treated with scrambled siRNA used as negative control [siNC]; treated with siEDC3-2) distinct neuronal elongations can be seen.
Scheller, Ute, Pfisterer, Kathrin, Uebe, Steffen, Ekici, Arif, Reis, André, Jamra, Rami, Ferrazzi, Fulvia   +6 more
openaire   +1 more source

Decapping activators in Saccharomyces cerevisiae act by multiple mechanisms

, 2010
Eukaryotic mRNA degradation often occurs in a process whereby translation initiation is inhibited and the mRNA is targeted for decapping. In yeast cells, Pat1, Scd6, Edc3, and Dhh1 all function to promote decapping by an unknown mechanism(s).
Haiwei Song (163763), Tracy Nissan (4583710), Roy Parker (315449), Purusharth Rajyaguru (16253459), Meipei She (16253462)   +4 more
core   +2 more sources