Results 161 to 170 of about 967,040 (315)

A Prospective Study of Perilesional Edema Evolution in Brain Mass Lesions before and after Surgery: Multimodal Analysis using Advanced Neuroimaging Techniques

, 2023
openPresupposti dello studio. L’edema perilesionale rappresenta spesso il substrato fisiopatologico delle manifestazioni cliniche per le quali i pazienti con lesioni espansive cerebrali giungono all’attenzione medica. Nelle metastasi cerebrali l’edema è
GARDENAL, GRETA
core  

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source

Topical nepafenac in the treatment of diabetic macular edema

, 2008
David Callanan, Patrick WilliamsTexas Retina Associates, Arlington, TX, USAPurpose: To determine the safety and efficacy of topical nepafenac 0.1% in the treatment of diabetic macular edema.Methods: A consecutive case series was performed of patients ...
David Callanan, Patrick Williams
core  

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Leakage, Migration, and Absorption of Autoserum Protein in Experimental Cerebral Edema : Light Microscopic Immunohistochemical Study

, 1987
Evans blue, horseradish peroxidase (HRP), and lanthanum have long been used as tracers in experimental brain edema, but these substances appear to modify in vivo reactions.
陣内, 敬文, 柴田, 尚武, 森, 和夫, 福嶋, 政昭   +3 more
core  

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Antiallergic effect of the atomized extract of rhizome of Curcuma longa, flowers of Cordia lutea and leaves of Annona muricata

Therapeutics and Clinical Risk Management, 2016
Jorge Arroyo-Acevedo,1–3 Cesar Franco-Quino,4,5 Eliberto Ruiz-Ramirez,4,5 Roberto Chávez-Asmat,1,6 Andrea Anampa-Guzmán,7,8 Ernesto Raéz-González,3 José Cabanillas-Coral9 1Pharmacology Laboratory, Institute of ...
Arroyo-Acevedo J, Franco-Quino C, Ruiz-Ramírez E, Chávez-Asmat R, Anampa-Guzmán A, Raéz-González E, Cabanillas-Coral J   +6 more
doaj  

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

Cancer Cell, 2007
T. Batchelor, A. Sorensen, E. di Tomaso, Wei-Ting Zhang, Du-Da G. Dan, K. Cohen, K. Kozak, D. Cahill, Poe-Jou Chen, Ming-Wang Zhu, M. Ancukiewicz, M. Mrugala, S. Plotkin, J. Drappatz, D. Louis, P. Ivy, D. Scadden, T. Benner, J. Loeffler, P. Wen, R. Jain   +20 more
semanticscholar   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source